Document Detail

Transcription factors in parathyroid development: lessons from hypoparathyroid disorders.
MedLine Citation:
PMID:  22082362     Owner:  NLM     Status:  MEDLINE    
Parathyroid developmental anomalies, which result in hypoparathyroidism, are common and may occur in one in 4,000 live births. Parathyroids, in man, develop from the endodermal cells of the third and fourth pharyngeal pouches, whereas, in the mouse they develop solely from the endoderm of the third pharyngeal pouches. In addition, neural crest cells that arise from the embryonic mid- and hindbrain also contribute to parathyroid gland development. The molecular signaling pathways that are involved in determining the differentiation of the pharyngeal pouch endoderm into parathyroid cells are being elucidated by studies of patients with hypoparathyroidism and appropriate mouse models. These studies have revealed important roles for a number of transcription factors, which include Tbx1, Gata3, Gcm2, Sox3, Aire1 and members of the homeobox (Hox) and paired box (Pax) families.
Irina V Grigorieva; Rajesh V Thakker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1237     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-01-05     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  24-38     Citation Subset:  IM    
Copyright Information:
© 2011 New York Academy of Sciences.
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MeSH Terms
Disease Models, Animal*
Gene Expression Regulation, Developmental
Hypoparathyroidism / genetics,  metabolism*
Parathyroid Glands / abnormalities*,  growth & development*,  physiology
Signal Transduction / genetics,  physiology
Transcription Factors / genetics,  physiology*
Grant Support
G1000467//Medical Research Council; G9825289//Medical Research Council
Reg. No./Substance:
0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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