| Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex. | |
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MedLine Citation:
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PMID: 20675579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Light signaling pathways and circadian clocks are inextricably linked and have profound effects on behavior in most organisms. Here, we used chromatin immunoprecipitation (ChIP) sequencing to uncover direct targets of the Neurospora crassa circadian regulator White Collar Complex (WCC). The WCC is a blue-light receptor and the key transcription factor of the circadian oscillator. It controls a transcriptional network that regulates ∼20% of all genes, generating daily rhythms and responses to light. We found that in response to light, WCC binds to hundreds of genomic regions, including the promoters of previously identified clock- and light-regulated genes. We show that WCC directly controls the expression of 24 transcription factor genes, including the clock-controlled adv-1 gene, which controls a circadian output pathway required for daily rhythms in development. Our findings provide links between the key circadian activator and effectors in downstream regulatory pathways. |
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Authors:
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Kristina M Smith; Gencer Sancar; Rigzin Dekhang; Christopher M Sullivan; Shaojie Li; Andrew G Tag; Cigdem Sancar; Erin L Bredeweg; Henry D Priest; Ryan F McCormick; Terry L Thomas; James C Carrington; Jason E Stajich; Deborah Bell-Pedersen; Michael Brunner; Michael Freitag |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-30 |
Journal Detail:
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Title: Eukaryotic cell Volume: 9 ISSN: 1535-9786 ISO Abbreviation: Eukaryotic Cell Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-28 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 101130731 Medline TA: Eukaryot Cell Country: United States |
Other Details:
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Languages: eng Pagination: 1549-56 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, Oregon State University, Corvallis, 97331-7305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromatin Immunoprecipitation Circadian Clocks* Circadian Rhythm Fungal Proteins / genetics, metabolism Gene Expression Regulation, Fungal* Gene Regulatory Networks Genome, Fungal / genetics High-Throughput Nucleotide Sequencing Light* Neurospora crassa / genetics, metabolism, physiology* Polymerase Chain Reaction Signal Transduction* Transcription Factors / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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2P01 GM068087/GM/NIGMS NIH HHS; AI43288/AI/NIAID NIH HHS; GM58529/GM/NIGMS NIH HHS; NS39546/NS/NINDS NIH HHS; R01 GM058529-13/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 0/Transcription Factors |
| Comments/Corrections | |
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