Document Detail

Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for neurospora white collar complex.
MedLine Citation:
PMID:  20675579     Owner:  NLM     Status:  MEDLINE    
Light signaling pathways and circadian clocks are inextricably linked and have profound effects on behavior in most organisms. Here, we used chromatin immunoprecipitation (ChIP) sequencing to uncover direct targets of the Neurospora crassa circadian regulator White Collar Complex (WCC). The WCC is a blue-light receptor and the key transcription factor of the circadian oscillator. It controls a transcriptional network that regulates ∼20% of all genes, generating daily rhythms and responses to light. We found that in response to light, WCC binds to hundreds of genomic regions, including the promoters of previously identified clock- and light-regulated genes. We show that WCC directly controls the expression of 24 transcription factor genes, including the clock-controlled adv-1 gene, which controls a circadian output pathway required for daily rhythms in development. Our findings provide links between the key circadian activator and effectors in downstream regulatory pathways.
Kristina M Smith; Gencer Sancar; Rigzin Dekhang; Christopher M Sullivan; Shaojie Li; Andrew G Tag; Cigdem Sancar; Erin L Bredeweg; Henry D Priest; Ryan F McCormick; Terry L Thomas; James C Carrington; Jason E Stajich; Deborah Bell-Pedersen; Michael Brunner; Michael Freitag
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-07-30
Journal Detail:
Title:  Eukaryotic cell     Volume:  9     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-28     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1549-56     Citation Subset:  IM    
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MeSH Terms
Chromatin Immunoprecipitation
Circadian Clocks*
Circadian Rhythm
Fungal Proteins / genetics,  metabolism
Gene Expression Regulation, Fungal*
Gene Regulatory Networks
Genome, Fungal / genetics
High-Throughput Nucleotide Sequencing
Neurospora crassa / genetics,  metabolism,  physiology*
Polymerase Chain Reaction
Signal Transduction*
Transcription Factors / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Fungal Proteins; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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