Document Detail

Transcription factor activation in response to cutaneous injury: role of AP-1 in reepithelialization.
MedLine Citation:
PMID:  11983002     Owner:  NLM     Status:  MEDLINE    
Reepithelialization is the process responsible for restoring an intact epidermis following cutaneous injury. A change in the activity of keratinocytes is required for reepithelialization to occur, and this is likely to be regulated by the altered expression of effector genes, mediated by transcription factors. The injury itself provides a stimulus for transcription factor activation either directly due to mechanical stress, or via paracrine mechanisms such as the release of growth factors from damaged cells. Members of the activator protein-1 family, in particular c-fos and c-jun, have been the most widely studied wound-induced transcription factors. The signal transduction pathways linking cellular injury to activator protein-1 stimulation appear to involve an increase in intracellular Ca2+ and activation of mitogen-activated protein kinases. Given that a number of genes involved in the reepithelialization of wounds are regulated by activator protein-1, a distinct role for this transcription factor in reepithelialization is beginning to emerge. This article reviews the evidence for activator protein-1 involvement in reepithelialization, with particular focus on the activation of this transcription factor in response to wounding, the second messenger/kinase pathways involved, and the modulation of downstream genes that have the capacity to regulate keratinocyte function.
Samantha Yates; Timothy E Rayner
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society     Volume:  10     ISSN:  1067-1927     ISO Abbreviation:  Wound Repair Regen     Publication Date:    2002 Jan-Feb
Date Detail:
Created Date:  2002-05-01     Completed Date:  2002-07-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9310939     Medline TA:  Wound Repair Regen     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-15     Citation Subset:  IM    
Co-operative Research Centre for Tissue Growth and Repair, The University of Adelaide Department of Surgery, The Queen Elizabeth Hospital, Woodville, Australia.
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MeSH Terms
Calcium / metabolism
Cell Differentiation
Cell Movement
Epidermis / physiopathology
Keratinocytes / cytology,  metabolism
Mitogen-Activated Protein Kinases / metabolism
Proto-Oncogene Proteins c-fos / metabolism
Proto-Oncogene Proteins c-jun / metabolism
Signal Transduction
Skin / injuries*,  physiopathology*
Transcription Factor AP-1 / metabolism*
Wound Healing / physiology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factor AP-1; 7440-70-2/Calcium; EC Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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