| Transcription factor RORα is critical for nuocyte development. | |
| | |
MedLine Citation:
|
PMID: 22267218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms. |
| | |
Authors:
|
See Heng Wong; Jennifer A Walker; Helen E Jolin; Lesley F Drynan; Emily Hams; Ana Camelo; Jillian L Barlow; Daniel R Neill; Veera Panova; Ute Koch; Freddy Radtke; Clare S Hardman; You Yi Hwang; Padraic G Fallon; Andrew N J McKenzie |
Related Documents
:
|
14749508 - Leptin signaling in the central nervous system and the periphery. 16399888 - The nitric oxide theory of aging revisited. 22033788 - Microparticles and micrornas: new players in the complex field of coagulation. 1323288 - Aba-induced 'lipid melting' and its reversal by umbelliferone in the plasmalemma of gua... 16633958 - The relationship between inflammation and the coagulation system. 789408 - Immune potential in human uraemia. 2. changes after regular haemodialysis therapy. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-01-22 |
Journal Detail:
|
Title: Nature immunology Volume: 13 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-20 Completed Date: 2012-04-04 Revised Date: 2012-05-04 |
Medline Journal Info:
|
Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 229-36 Citation Subset: IM |
Affiliation:
|
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Differentiation* Interleukin-7 / immunology, metabolism Leukocytes / cytology, immunology*, metabolism Mice Nippostrongylus / immunology Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics, immunology*, metabolism Signal Transduction Strongylida Infections / immunology Thymocytes / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-7; 0/Nuclear Receptor Subfamily 1, Group F, Member 1; 0/Rora protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncano...
Next Document: A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and dif...