Document Detail

Transcription factor GATA-6 in the human adrenocortex: association with adrenal development and aging.
MedLine Citation:
PMID:  17785913     Owner:  NLM     Status:  MEDLINE    
Transcription factor GATA-6 has been demonstrated to be expressed in the human fetal and adult adrenal cortex and has been postulated to play an important role in adrenal steroid biosynthesis. However, the status for GATA-6 expression has not been examined in detail especially in relation to adrenal development and aging. Therefore, in this study, we analyzed GATA-6 expression in 11 human fetal adrenals and 19 adrenal glands after birth using immunohistochemistry. In the fetal adrenals, the status of GATA-6 immunoreactivity in the definitive zone was significantly and directly correlated with ages of development (P<0.05) but in the fetal zone was significantly and inversely correlated with ages of development (P<0.05). After birth, GATA-6 was more abundant in the zona fasciculata compared to other zones (P<0.05) but was not related to aging of the subject. These results suggest that GATA-6 expression is involved in the regulation of corticosteroid production in both the human fetal and adult adrenals, and the changes of intra-adrenal GATA-6 expression in the human fetal adrenal plays important roles in developmental changes of both the definitive and fetal zones.
Yasuhiro Nakamura; Takashi Suzuki; Hironobu Sasano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-04
Journal Detail:
Title:  Endocrine journal     Volume:  54     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-20     Completed Date:  2008-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  783-9     Citation Subset:  IM    
Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Adrenal Cortex / embryology*,  growth & development,  metabolism
Adrenal Cortex Hormones / metabolism
Aging / metabolism,  physiology*
Child, Preschool
Embryo, Mammalian
Fetus / metabolism
GATA6 Transcription Factor / metabolism*,  physiology
Middle Aged
Sex Characteristics
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/GATA6 Transcription Factor

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