| Transcription of LINE-derived sequences in exercise-induced stress in horses. | |
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MedLine Citation:
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PMID: 21070272 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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A large proportion of mammalian genomes is represented by transposable elements (TE), most of them being long interspersed nuclear elements 1 (LINE-1 or L1). An increased expression of LINE-1 elements may play an important role in cellular stress-related conditions exerting drastic effects on the mammalian transcriptome. To understand the impact of TE on the known horse transcriptome, we masked the horse EST database, pointing out that the amount is consistent with other major vertebrates. A previously developed transcript-derived fragments (TDFs) dataset, deriving from exercise-stimulated horse peripheral blood mononuclear cells (PBMCs), was found to be enriched with L1 (26.8% in terms of bp). We investigated the involvement of TDFs in exercise-induced stress through bioinformatics and gene expression analysis. Results indicate that LINE-derived sequences are not only highly but also differentially expressed during physical effort, hinting at interesting scenarios in the regulation of gene expression in relation to exercise. |
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Authors:
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S Capomaccio; A Verini-Supplizi; G Galla; N Vitulo; G Barcaccia; M Felicetti; M Silvestrelli; K Cappelli |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Animal genetics Volume: 41 Suppl 2 ISSN: 1365-2052 ISO Abbreviation: Anim. Genet. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8605704 Medline TA: Anim Genet Country: England |
Other Details:
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Languages: eng Pagination: 23-7 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors, Journal compilation © 2010 Stichting International Foundation for Animal Genetics. |
Affiliation:
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CSCS-DPDCV, Faculty of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy. vete7@unipg.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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