Document Detail

Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences.
MedLine Citation:
PMID:  11850176     Owner:  NLM     Status:  MEDLINE    
Organogenesis requires coordination between developmental programs and cell cycle progression. The Cip/Kip families of cyclin-dependent kinase inhibitor (CKI) are main effectors linking these two programs. In many instances, expression of Cip/Kip CKIs are increased abruptly in cells entering their last mitotic cycle, suggesting that CKI expression is developmentally regulated. Expression of Dacapo (Dap), a Drosophila Cip/Kip CKI, is transiently up-regulated immediately before cells enter G1 arrest. Here we report that dap transcription is controlled by modular arrays of tissues specific cis-regulatory elements. Furthermore, we identified pan-neural Prospero as a regulator of dap transcription in the developing nervous system, providing an example how tissue-specific developmental programs can be linked to cell cycle progression.
Te-Hui Liu; Ling Li; Harald Vaessin
Related Documents :
17632456 - Solid pseudopapillary neoplasms of the pancreas show an interruption of the wnt-signali...
11504716 - Cyclin a-dependent phosphorylation of the ets-related protein, mef, restricts its activ...
7612496 - In situ hybridization detection of cyclin d1 mrna in centrocytic/mantle cell lymphoma.
7542356 - Selective repression of growth-regulating cdk2, cyclin e and e2f1 genes in human cell s...
20410206 - Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression ...
7846076 - Vascular endothelial growth factor/vascular permeability factor expression in a mouse m...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Mechanisms of development     Volume:  112     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  25-36     Citation Subset:  IM    
Department of Molecular Genetics, Neurobiotechnology Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Cycle
Central Nervous System / embryology
Crosses, Genetic
Drosophila Proteins*
Drosophila melanogaster
Epidermis / embryology
Gene Expression Regulation, Developmental*
In Situ Hybridization
Microscopy, Fluorescence
Models, Genetic
Nuclear Proteins / genetics*,  metabolism*
Peripheral Nervous System / embryology
Transcription, Genetic*
Reg. No./Substance:
0/Dacapo protein, Drosophila; 0/Drosophila Proteins; 0/Nuclear Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Derivation in culture of primordial germ cells from cells of the mouse epiblast: phenotypic inductio...
Next Document:  Overexpression of the secreted factor Mig30 expressed in the Spemann organizer impairs morphogenetic...