Document Detail


Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences.
MedLine Citation:
PMID:  11850176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Organogenesis requires coordination between developmental programs and cell cycle progression. The Cip/Kip families of cyclin-dependent kinase inhibitor (CKI) are main effectors linking these two programs. In many instances, expression of Cip/Kip CKIs are increased abruptly in cells entering their last mitotic cycle, suggesting that CKI expression is developmentally regulated. Expression of Dacapo (Dap), a Drosophila Cip/Kip CKI, is transiently up-regulated immediately before cells enter G1 arrest. Here we report that dap transcription is controlled by modular arrays of tissues specific cis-regulatory elements. Furthermore, we identified pan-neural Prospero as a regulator of dap transcription in the developing nervous system, providing an example how tissue-specific developmental programs can be linked to cell cycle progression.
Authors:
Te-Hui Liu; Ling Li; Harald Vaessin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Mechanisms of development     Volume:  112     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  25-36     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Neurobiotechnology Center, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle
Central Nervous System / embryology
Crosses, Genetic
Drosophila Proteins*
Drosophila melanogaster
Epidermis / embryology
Gene Expression Regulation, Developmental*
Immunohistochemistry
In Situ Hybridization
Microscopy, Fluorescence
Models, Genetic
Nuclear Proteins / genetics*,  metabolism*
Peripheral Nervous System / embryology
Transcription, Genetic*
Chemical
Reg. No./Substance:
0/Dacapo protein, Drosophila; 0/Drosophila Proteins; 0/Nuclear Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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