Document Detail

Transcranial sonography of the substantia nigra and MIBG myocardial scintigraphy: complementary role in the diagnosis of Parkinson's disease.
MedLine Citation:
PMID:  18691928     Owner:  NLM     Status:  MEDLINE    
Both transcranial sonography (TCS) of the substantia nigra (SN) and metaiodobenzylguanidine (MIBG) myocardial scintigraphy have been determined to be useful for the diagnosis of Parkinson's disease (PD). In the present study, we performed both tests in 65 consecutive Japanese patients with idiopathic PD. In 30 PD patients (46.2%), the midbrain was adequately displayed by TCS allowing quantitative measurements of SN hyperechogenic areas. No significant correlation was found between the area of SN echogenicity and the reduction of myocardial uptake of MIBG. However, if the cut-off value was appropriately set, 29 patients (97%) were identified as abnormal by combined TCS and MIBG myocardial scintigraphy. Since TCS and MIBG myocardial scintigraphy can distinctively detect PD-related pathological phenomenon, it is expected that the combination of these tests could contribute to an accurate diagnosis of PD.
Yoshinori Kajimoto; Hideto Miwa; Masae Okawa-Izawa; Masaya Hironishi; Tomoyoshi Kondo
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Publication Detail:
Type:  Journal Article     Date:  2008-08-08
Journal Detail:
Title:  Parkinsonism & related disorders     Volume:  15     ISSN:  1873-5126     ISO Abbreviation:  Parkinsonism Relat. Disord.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513583     Medline TA:  Parkinsonism Relat Disord     Country:  England    
Other Details:
Languages:  eng     Pagination:  270-2     Citation Subset:  IM    
Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-8510, Japan.
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MeSH Terms
Aged, 80 and over
Guanidines / diagnostic use*
Middle Aged
Myocardial Perfusion Imaging / methods*
Parkinson Disease / diagnosis*
Radiopharmaceuticals / diagnostic use*
Statistics, Nonparametric
Substantia Nigra* / pathology,  radionuclide imaging,  ultrasonography
Ultrasonography, Doppler, Transcranial / methods*
Reg. No./Substance:
0/Guanidines; 0/Radiopharmaceuticals; 2211-57-6/benzylguanidine

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