| Transcranial sonography in pantothenate kinase-associated neurodegeneration. | |
| | |
MedLine Citation:
|
PMID: 22057405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
After it was reported that increased tissue iron concentrations were associated with increased echogenicity of the substantia nigra (SN) obtained with transcranial sonography (TCS) in animal and postmortem studies, our goal was to use this method in a disorder characterized with iron accumulation in human brain tissue. Therefore, magnetic resonance imaging (MRI) and TCS were conducted in 5 unrelated patients with pantothenate kinase-associated neurodegeneration (PKAN), caused by PANK2 mutations. All patients had an eye of the tiger sign. Hypointense lesions on the T2-weighted MRI images were restricted to the globus pallidus (GP) and SN. TCS also revealed bilateral hyperechogenicity restricted to the LN and SN, with normal DTV values. Both TCS and MRI studies in PKAN patients are in accordance with the pathological findings that accumulation of iron, even in advanced cases, is restricted to the GP and SN, suggesting selective involvement of these structures. |
| | |
Authors:
|
Vladimir S Kostić; Marina Svetel; Milija Mijajlović; Aleksandra Pavlović; Milica Ječmenica-Lukić; Dušan Kozić |
Related Documents
:
|
21723205 - Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioni... 3915675 - Real-time three-dimensional graphic reconstructions using brown-roberts-wells frame coo... 22119225 - Multimodality functional imaging of spontaneous canine tumors using (64)cu-atsm and (18... 22011375 - Use of magnetic resonance imaging in assessment of constrictive pericarditis: a morocca... 9445195 - Amyloidomas of the nervous system: a monoclonal b-cell disorder with monotypic amyloid ... 3763935 - Retrograde ileography: value of glucagon. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-5 |
Journal Detail:
|
Title: Journal of neurology Volume: - ISSN: 1432-1459 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0423161 Medline TA: J Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
School of Medicine, Institute of Neurology CCS, University of Belgrade, Ul. Dr Subotića 6, 11000, Belgrade, Serbia, vladimir.s.kostic@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sporadic juvenile amyotrophic lateral sclerosis caused by mutant FUS/TLS: possible association of me...
Next Document: The hemodynamic status within 24 h after intravenous thrombolysis predicts infarct growth in acute ...