| Transcranial magnetic stimulation differentially affects speed and direction judgments. | |
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MedLine Citation:
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PMID: 11685392 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to determine whether humans' judgments about the speed and direction of moving stimuli was differentially affected by transcranial magnetic stimulation (TMS). Subjects viewed two successively presented moving stimuli that differed from each other both in speed and direction of motion. Single-pulse TMS was applied either medially (approximately 2 cm above the inion) or laterally (approximately 5 cm lateral to and 4 cm above the inion), while subjects judged the speed and direction differences. The physical stimulation (visual and TMS) was identical on the two tasks, as was discriminability (d') when TMS was not applied. We found significant criterion (beta) shifts on the speed discrimination task at both stimulation sites. Specifically, on TMS trials the proportion of "slower" judgments increased significantly, consistent with subjective reports that stimuli often appeared to slow when TMS was applied. The subjective reports indicated no corresponding change in perceived direction. We also found that speed discriminability was impaired significantly more than direction discriminability, but only when TMS was applied medially. Indeed, after controlling for TMS-related changes in reaction time, speed discriminability was impaired significantly, while direction discriminability remained largely intact. This dissociation suggests that the sensory response constraining speed discrimination is at least partially independent from the sensory response constraining direction discrimination. Combined with previous psychophysical data, the present data suggest a double dissociation between speed and direction discrimination in humans. |
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Authors:
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N Matthews; B Luber; N Qian; S H Lisanby |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale Volume: 140 ISSN: 0014-4819 ISO Abbreviation: Exp Brain Res Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-30 Completed Date: 2001-12-18 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0043312 Medline TA: Exp Brain Res Country: Germany |
Other Details:
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Languages: eng Pagination: 397-406 Citation Subset: IM |
Affiliation:
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Center For Neurobiology and Behavior, Columbia University, USA. matthewsn@denison.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Discrimination Learning / physiology Electric Stimulation / adverse effects Female Humans Illusions / physiology* Male Middle Aged Motion Perception / physiology* Neuropsychological Tests Orientation / physiology* Photic Stimulation Psychomotor Performance / physiology* Reaction Time / physiology Transcranial Magnetic Stimulation / adverse effects* Visual Cortex / physiology* Visual Pathways / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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F32 EY06969/EY/NEI NIH HHS; MH01577/MH/NIMH NIH HHS; MH54125/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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