Document Detail

Transcranial magnetic stimulation of the cerebellum in essential tremor: a controlled study.
MedLine Citation:
PMID:  11890845     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Growing evidence implicates an overactivity of the cerebellum in the pathophysiology of essential tremor. In a small series of patients, we explored the acute effects and therapeutic possibilities of low-frequency repetitive transcranial magnetic stimulation (rTMS) of the cerebellum in patients with essential tremor in a double-blind, crossover, placebo-controlled design. METHODS: Ten patients with essential tremor underwent an active and a sham rTMS session, at a 1-week interval. The rTMS was performed with a focal double 70-mm butterfly coil (maximum peak field of 2.2 T) applied 2 cm below the inion. Each session consisted of 30 trains of 10-second duration separated by 30-second pauses, at 100% of the maximum output intensity and at 1-Hz frequency. Major evaluation outcomes were the score on the Tremor Clinical Rating Scale and accelerometric recordings obtained before (-5 minutes), immediately after (+5 minutes), and 1 hour after (+60 minutes) each rTMS session. Both clinical and accelerometric measurements were obtained by a blinded neurologist. RESULTS: On the +5-minute assessment, active rTMS produced a notable tremor improvement compared with sham rTMS, as evidenced by a significant reduction in scores on the clinical rating scale and accelerometric values. At +60 minutes, no clinical or accelerometric benefit was evidenced. No adverse effects of rTMS were observed. CONCLUSIONS: This exploratory study of the potential therapeutic properties of rTMS on essential tremor showed an acute antitremor effect. Further investigation in search of a more lasting benefit is warranted.
Alexandre Gironell; Jaime Kulisevsky; José Lorenzo; Manel Barbanoj; Berta Pascual-Sedano; Pilar Otermin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of neurology     Volume:  59     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-03-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  AIM; IM    
Servei de Neurologia, Hospital de Sant Pau, Av Sant Antoni Ma Claret 167, 08025 Barcelona, Catalonia, Spain.
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MeSH Terms
Cerebellum / physiopathology*
Cross-Over Studies
Double-Blind Method
Electric Stimulation Therapy* / adverse effects
Middle Aged
Patient Satisfaction
Severity of Illness Index
Time Factors
Transcranial Magnetic Stimulation*
Tremor / physiopathology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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