| Transcranial contrast imaging of cerebral perfusion in patients with space-occupying intracranial lesions. | |
| | |
MedLine Citation:
|
PMID: 16567439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of this study was to evaluate a deficit in cerebral perfusion after administration of the contrast agent SonoVue (Bracco Altana Pharma, Konstanz, Germany) in patients with intracranial space-occupying lesions. METHODS: We used transcranial duplex sonography to examine 10 healthy volunteers and 4 patients. Of the patients, one 55-year-old woman had an intracranial glioblastoma; one 54-year-old woman had an intracranial hemorrhage; and one 49-year-old woman and one 69-year-old man had a malignant middle cerebral artery infarction. A decompressive craniectomy was performed in the 2 patients with malignant middle cerebral artery infarction. Triggered images with pulsing intervals of 1000 milliseconds were used for the evaluation of time-intensity curves in several regions of interest. The mechanical index was set at 1.6; in patients with a craniectomy, the mechanical index was set at 1.1. RESULTS: In all patients, the perfusion deficit could be recognized in the ipsilateral hemisphere. The superimposition of the sonographic images with those from computed tomography or magnetic resonance imaging showed a good correspondence in shape and size in patients with a craniectomy. In patients without a craniectomy, a rough correspondence with findings from magnetic resonance imaging or computed tomography could be recognized. CONCLUSIONS: By using contrast-enhanced transcranial duplex sonography, it is possible to image the perfusion deficit in cerebral microcirculation in patients with intracranial space-occupying lesions. These results should be confirmed by more pathologic cases and correlated with magnetic resonance imaging and other neuroimaging techniques. Additionally, further technical development in sonographic systems is necessary to improve the diagnostics of cerebral perfusion deficit. |
| | |
Authors:
|
Eva Bartels; Hans-Joachim Bittermann |
Related Documents
:
|
18034339 - Immediate ct findings following embolization of cerebral aneurysms: suggestion of blood... 9806139 - Neuroradiologic aspects of west syndrome. 1337769 - Ct and mri: prognostic tools in patients with aids and neurological deficits. 615219 - Reversibility of cerebral atrophy in anorexia nervosa and cushing's syndrome. 13679259 - Short-term changes in cerebral microhemodynamics after carotid stenting. 3580739 - Cortical blindness in toxaemia of pregnancy: findings on computed tomography. 8853169 - The rheumatoid knee before and after arthrocentesis and prednisolone injection: evaluat... 19934069 - Radiation dose evaluation in 64-slice ct examinations with adult and paediatric anthrop... 870939 - The tentorium in axial section. i. normal ct appearance and non-neoplastic pathology. |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 25 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-03-28 Completed Date: 2006-09-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
|
Languages: eng Pagination: 499-507 Citation Subset: IM |
Affiliation:
|
Department of Clinical Neurophysiology, Georg-August-University Göttingen, Robert-Koch-Strasse 40, D-37075 Göttingen, Germany. bartels.eva@t-online.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Brain / blood supply* Cerebrovascular Circulation* Cerebrovascular Disorders / ultrasonography* Contrast Media Female Humans Male Phospholipids / diagnostic use* Reproducibility of Results Sensitivity and Specificity Sulfur Hexafluoride / diagnostic use* Ultrasonography, Doppler, Transcranial / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation between estimates of tumor perfusion from microbubble contrast-enhanced sonography and d...
Next Document: Three-dimensional ultrasonographic reslicing of the fetal brain to assist prenatal diagnosis of cent...