| Transcranial contrast diminution imaging of the human brain: a pilot study in healthy volunteers. | |
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MedLine Citation:
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PMID: 12498938 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Analysis of contrast diminution kinetics after bubble destruction is a new aspect in harmonic imaging. The purpose of this study was to investigate this approach to human cerebral perfusion. A total of 12 healthy volunteers were investigated transtemporally (Philips SONOS 5500, S4-probe, 1.8 to 3.6 MHz, 10 cm) at two ultrasound (US) contrast agent (UCA) infusion rates (0.5 and 1.0 mL/min of Optison). After achieving a steady-state, a set of 12 US pulses (6.67 Hz, MI 1.6) was applied. Time-intensity plots of three regions-of-interest (ROIs) (thalamus, white matter and cortex) were analyzed, using an exponential curve fit (I((t)) = I(0)e(-betat) + B). A total of 20 of 20 successful investigations showed a signal decrease after pulsed US application. In all cases, it was possible to generate exponential time-intensity curves. Half-life (T(1/2) = ln2/beta) and baseline intensity (B) showed a significant dependence on infusion rate (p = 0.01). At 1.0 mL/min, T(1/2) also depended on investigation depth (p = 0.01). It is possible to assess contrast diminution kinetics in human cerebral microcirculation. This new approach may provide additional information on cerebral perfusion within a short investigation time. |
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Authors:
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Karsten Meyer; Günter Seidel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 28 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2002 Nov-Dec |
Date Detail:
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Created Date: 2002-12-24 Completed Date: 2003-04-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1433-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albumins / diagnostic use*, pharmacokinetics Cerebrovascular Circulation* Contrast Media* / pharmacokinetics Drug Administration Schedule Female Fluorocarbons / diagnostic use*, pharmacokinetics Half-Life Humans Image Processing, Computer-Assisted / methods Male Microcirculation Microspheres Middle Aged Pilot Projects Ultrasonography, Doppler, Transcranial / methods* |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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