Document Detail

Transcranial Doppler sonography: nitrous oxide and cerebral blood flow velocity in children.
MedLine Citation:
PMID:  1752019     Owner:  NLM     Status:  MEDLINE    
To determine the effect of nitrous oxide (N2O) on cerebral blood flow velocity (CBFV) and cerebrovascular resistance index (RI+) in children, ten ASA physical status I or II patients aged one to eight years old, scheduled for urological procedures, were studied. Anaesthesia was induced with thiopentone 2, fentanyl 5 and diazepam 0.3 Muscular relaxation was ensured by using vecuronium 0.1 After tracheal intubation, anaesthesia was randomly assigned to either a mixture of air in oxygen (N2/O2) or 70% N2O in oxygen (N2O/O2) producing an FIO2 of 30%. Three sets of measurements of CBFV and RI+ were made with both gas mixtures. The CBFV and RI+ were measured in the middle cerebral artery (MCA) with a transcranial Doppler monitor. Measurements were made while using the initial gas mixture, then the second gas mixture was administered, and finally, the patient again was given the initial gas mixture. A continuous caudal epidural or lumbar epidural block was performed before skin incision. Neuromuscular blockade was maintained with vecuronium 0.05 Temperature, heart rate, end-tidal CO2, arterial oxygen saturation, haematocrit and arterial blood pressure were maintained constant. Ventilation was adjusted to achieve normocapnia. The CBFV increased when 70% N2/O2 was replaced by 70% N2O/O2 (P less than 0.05) while the CBFV decreased when 70% N2/O2 was readministered (P less than 0.05). Likewise, the CBFV decreased when 70% N2O/O2 was replaced by 70% N2/O2 (P less than 0.05) while the CBFV increased when 70% N2O/O2 was readministered (P less than 0.05).
J E Leon; B Bissonnette
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  38     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  974-9     Citation Subset:  IM    
Department of Anaesthesia, Hospital for Sick Children, University of Toronto, Ontario, Canada.
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MeSH Terms
Anesthesia, Inhalation
Blood Flow Velocity / drug effects*
Brain / blood supply*
Cerebral Arteries / drug effects,  ultrasonography
Cerebrovascular Circulation / drug effects*
Child, Preschool
Echoencephalography* / methods
Nitrogen / administration & dosage
Nitrous Oxide / administration & dosage,  pharmacology*
Oxygen / administration & dosage
Time Factors
Vascular Resistance / drug effects*
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 7727-37-9/Nitrogen; 7782-44-7/Oxygen
Erratum In:
Can J Anaesth 1992 Apr;39(4):409

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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