Document Detail

Transcranial Doppler monitoring in hypertensive patients during physical exercise.
MedLine Citation:
PMID:  11641582     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the diagnostic value of a combined method, i.e. ergometer cycling with continuous bilateral transcranial Doppler monitoring (TCD) to detect cerebral hemodynamic abnormalities in recently diagnosed hypertensive patients. METHODS: 30 neurologically symptom-free, nontreated patients with essential hypertension and 30 age- and sex-matched controls were studied. Carotid ultrasound, resting ECG and blood parameters were investigated. Cycling ergometry was performed according to the WHO protocol. Blood pressure, heart rate, end-tidal CO2 (etCO2) and bilateral middle cerebral artery (MCA) blood flow velocity (MV) were monitored. RESULTS: At rest, MV in the MCA did not differ significantly between controls and hypertensive subjects. MV continuously increased in controls until the end of loading whereas a plateau was reached at 4 min in hypertensive subjects. During 6 min of cycling, the time course of absolute values of MV in the MCA and that of the changes in the ratio of mean velocity/end-tidal CO2 (DeltaMV/DeltaetCO2) differed significantly between hypertensive subjects and controls (p = 0.03 and p = 0.02, respectively). CONCLUSION: Ergometer cycling combined with TCD revealed altered vasoreactivity, therefore this may be a sensitive method for the detection of early hemodynamic impairment in nontreated hypertensive subjects.
M T Magyar; A Valikovics; D Bereczki; A Ficzere; I Czuriga; L Csiba
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  12     ISSN:  1015-9770     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-19     Completed Date:  2002-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  186-91     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Departments of Neurology and Cardiology, University of Debrecen, Health Science Center, Debrecen, Hungary.
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MeSH Terms
Blood Flow Velocity
Carbon Dioxide
Cerebral Arteries / physiopathology
Cerebrovascular Circulation
Exercise Test
Heart Rate
Hypertension / diagnosis,  physiopathology*,  ultrasonography*
Middle Aged
Reference Values
Sensitivity and Specificity
Tidal Volume
Ultrasonography, Doppler, Transcranial*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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