| Transcranial Doppler enhanced thrombolysis for embolic occlusion of major cerebral arteries. | |
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MedLine Citation:
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PMID: 20591241 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Summary: For the treatment of 11 patients with hyperacute embolic occlusion of major cerebral arteries (ten with occlusion of middle cerebral artery and one with occlusion of basilar artery), TCDenhanced thrombolysis (TCDET) was performed in combination with ultrasound irradiation, using diagnostic transcranial Doppler (TCD) (TC2-64B: 2MHz, 100mW/cm(2), pulsed wave) (TCDET group), and the effectiveness of this procedure was compared with that of local intra-arterial fibrinolysis (LIF) in 45 patients with embolic occlusion of the middle cerebral artery (LIF group). Regarding dose of TPA, the LIF group used 1046.7 +/- 607.8 units and the TCDET group 700.0 +/- 431.3 units (p < 0.05). Regarding time technically required to attain recanalization, the LIF group required 68.2 minutes, and the TCDET group 28.6 minutes. A good outcome was noted in 60.8% of the LIF group and 64% of the TCDET group. Haemorrhagic transformation was observed in 7.8% of the LIF group and in 0% of the TCDET group. No complications due to TCD irradiation were observed in the TCDET group. These findings suggest that TCDET can be an effective method of achieving recanalization. |
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Authors:
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T Yamanome; M Sasoh; Y Kubo; Y Nishikawa; H Endoh; N Satoh; A Ogawa |
Publication Detail:
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Type: Journal Article Date: 2004-10-22 |
Journal Detail:
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Title: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Volume: 9 ISSN: 1591-0199 ISO Abbreviation: Interv Neuroradiol Publication Date: 2003 May |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2012-10-02 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 9602695 Medline TA: Interv Neuroradiol Country: Italy |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: - |
Affiliation:
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Department of Neurosurgery, Iwate Prefectural Ofunato Hospital; Iwate, Japan. |
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