Document Detail

Transcranial Doppler characteristics of different embolic materials during in vivo testing.
MedLine Citation:
PMID:  12116745     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The authors investigated whether ultrasonic characteristics of embolic signals could be used to differentiate embolic composition. MATERIALS AND METHODS: The authors analyzed high-intensity transient signals (HITS) from 3 patients with patent foramen ovale during the bubble contrast test and during total joint replacement surgery. In 3 anesthetized dogs, latex microspheres, fat particles, and air bubbles were injected into the internal carotid artery and HITS were identified in the cerebral circulation. The area under the receiver operating characteristic curve quantified the usefulness of each measure to distinguish embolic composition. RESULTS: In humans, HITS intensity (area: 0.80) and frequency (area: 0.73) but not duration (area: 0.32) were useful to distinguish air bubbles from presumed solid emboli. In animals, intensity distinguished microspheres from air (area: 0.94) and microspheres from fat (area: 0.94) but was less useful for fat and air (area: 0.64). The duration (area: 0.54-0.76) and frequency (area: 0.54-0.63) were poor discriminators. CONCLUSION: The HITS intensity best distinguished embolic composition. Particle size should be taken into account in future research.
Rosendo A Rodriguez; Allan Giachino; Martin Hosking; Howard J Nathan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  12     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-15     Completed Date:  2002-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Department of Anesthesia, Cardiac Division, University of Ottawa Heart Institute, Room H-341, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.
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MeSH Terms
Embolism / ultrasonography*
Intracranial Embolism / ultrasonography
Particle Size
ROC Curve
Ultrasonography, Doppler, Transcranial*

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