Document Detail


Transcatheter embolization of pulmonary arteriovenous malformations in Rendu-Osler-Weber disease.
MedLine Citation:
PMID:  10201056     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interest in the treatment of the pulmonary arteriovenous malformations (PAVMs) that occur in approximately one-third of patients with Rendu-Osler-Weber (ROW) disease (hereditary haemorrhagic telangiectasia) has recently been renewed. PAVMs can now be occluded safely by the transvenous placement of detachable balloons or metal coils, thus avoiding the many potential complications of thoracotomy. This study analyses the treatment of eight PAVMs in four ROW patients by transcatheter embolization using detachable balloons or metal coils. After embolization, the mean right-to-left shunt fraction significantly decreased from 39.1 +/- 5.1% to 11.9 +/- 1.1% (P < 0.05) and PaO2 significantly increased from 53.3 +/- 7.8 torr to 76.2 +/- 8.4 torr (P < 0.05). No serious complications occurred. One detachable balloon was deflated, but no recanalization occurred. We conclude that transcatheter embolization is a safe and efficacious treatment for PAVMs associated with ROW disease. Long-term studies are now needed to determine the risk of recanalization in this treatment.
Authors:
T Shioya; M Sano; M Kagaya; N Ito; A Watanabe; K Sato; T Ito; M Sasaki; M Hashimoto; M Miura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  3     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-05-17     Completed Date:  1999-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  277-80     Citation Subset:  IM    
Affiliation:
Department of Physical Therapy, Akita University College of Allied Medical Science, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteriovenous Malformations / therapy*
Balloon Dilatation / instrumentation
Embolization, Therapeutic / instrumentation,  methods*
Equipment Failure
Female
Humans
Lung / blood supply*
Male
Metals
Middle Aged
Oxygen / blood
Pulmonary Circulation / physiology
Safety
Telangiectasia, Hereditary Hemorrhagic / therapy*
Chemical
Reg. No./Substance:
0/Metals; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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