Document Detail

Transcatheter closure of perimembranous ventricular septal defects in infants and children using the Amplatzer perimembranous ventricular septal defect occluder.
MedLine Citation:
PMID:  17398197     Owner:  NLM     Status:  MEDLINE    
There are very few published reports of the transcatheter closure of perimembranous ventricular septal defects (PMVSDs) using the Amplatzer PMVSD occluder with encouraging initial results. This report presents initial and 1-year results from 54 patients with PMVSDs who underwent transcatheter closure at 5 different institutions with the Amplatzer PMVSD occluder. Sixty-five patients with PMVSDs were enrolled at 5 European centers. Eleven of the 65 patients did not fulfill the patient selection criteria at the initial echocardiographic evaluation or at cardiac catheterization. As a result, a total of 54 patients underwent attempted transcatheter closure using the Amplatzer PMVSD occluder. The median age of the patients was 5.1+/-3.6 years (range 0.3 to 13), and the median weight 18.5+/-10.3 kg (range 5 to 45). Devices were permanently implanted in 49 of 54 patients. Complete occlusion of the communication at 1-year follow-up was observed in 46 of 49 patients (94%). Main early procedural complications included (1) device embolization (2 patients), (2) severe bradycardia with hemodynamic compromise (2 patients), and (3) Mobitz II (2:1) heart block (1 patient). Late procedural complications included complete heart block (1 patient). No other complications were observed during follow-up. In conclusion, the Amplatzer PMVSD occluder is promising device that can be used for transcatheter closure in selected patients with PMVSDs. Further studies and long-term follow-up are required before this technique enters routine clinical practice.
Basil Vasilios D Thanopoulos; Michael L Rigby; Evangelos Karanasios; Christodoulos Stefanadis; Nico Blom; Jaap Ottenkamp; Armine Zarayelyan
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2007-02-16
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-04-25     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  984-9     Citation Subset:  AIM; IM    
Department of Cardiology, Aghia Sophia Children's Hospital, and University of Athens, Greece.
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MeSH Terms
Child, Preschool
Echocardiography, Doppler, Color
Echocardiography, Transesophageal
Equipment Design
Equipment Failure
Follow-Up Studies
Heart Catheterization / adverse effects,  instrumentation*
Heart Septal Defects, Ventricular / therapy*,  ultrasonography
Research Design
Treatment Outcome
Comment In:
Am J Cardiol. 2007 Oct 1;100(7):1185-6   [PMID:  17884388 ]

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