Document Detail


Transcatheter closure of perimembranous ventricular septal defects in infants and children using the Amplatzer perimembranous ventricular septal defect occluder.
MedLine Citation:
PMID:  17398197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are very few published reports of the transcatheter closure of perimembranous ventricular septal defects (PMVSDs) using the Amplatzer PMVSD occluder with encouraging initial results. This report presents initial and 1-year results from 54 patients with PMVSDs who underwent transcatheter closure at 5 different institutions with the Amplatzer PMVSD occluder. Sixty-five patients with PMVSDs were enrolled at 5 European centers. Eleven of the 65 patients did not fulfill the patient selection criteria at the initial echocardiographic evaluation or at cardiac catheterization. As a result, a total of 54 patients underwent attempted transcatheter closure using the Amplatzer PMVSD occluder. The median age of the patients was 5.1+/-3.6 years (range 0.3 to 13), and the median weight 18.5+/-10.3 kg (range 5 to 45). Devices were permanently implanted in 49 of 54 patients. Complete occlusion of the communication at 1-year follow-up was observed in 46 of 49 patients (94%). Main early procedural complications included (1) device embolization (2 patients), (2) severe bradycardia with hemodynamic compromise (2 patients), and (3) Mobitz II (2:1) heart block (1 patient). Late procedural complications included complete heart block (1 patient). No other complications were observed during follow-up. In conclusion, the Amplatzer PMVSD occluder is promising device that can be used for transcatheter closure in selected patients with PMVSDs. Further studies and long-term follow-up are required before this technique enters routine clinical practice.
Authors:
Basil Vasilios D Thanopoulos; Michael L Rigby; Evangelos Karanasios; Christodoulos Stefanadis; Nico Blom; Jaap Ottenkamp; Armine Zarayelyan
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2007-02-16
Journal Detail:
Title:  The American journal of cardiology     Volume:  99     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-04-25     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  984-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Aghia Sophia Children's Hospital, and University of Athens, Greece. vasiliosthanopoulos@usa.net
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Echocardiography, Doppler, Color
Echocardiography, Transesophageal
Equipment Design
Equipment Failure
Europe
Follow-Up Studies
Heart Catheterization / adverse effects,  instrumentation*
Heart Septal Defects, Ventricular / therapy*,  ultrasonography
Humans
Infant
Research Design
Treatment Outcome
Comments/Corrections
Comment In:
Am J Cardiol. 2007 Oct 1;100(7):1185-6   [PMID:  17884388 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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