Document Detail

Transcatheter arterial procedures in the treatment of patients with hepatocellular carcinoma: a review of literature.
MedLine Citation:
PMID:  12791428     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Transcatheter arterial procedures (TAP) have been widely used to treat hepatocellular carcinoma (HCC) in several clinical settings (advanced and neoadjuvant), and contraindications and secondary effects have been clearly described. However, it is still unclear which patients should be selected for treatment, which procedures should be used, in particular whether or not to add an antiblastic agent to embolization, and if the treatment provides a survival advantage in patient with HCC. METHODS: We conducted a Medline search for all study reports published until May 2002. Data from randomised studies were evaluated in detail. RESULTS: Data on the use of TAP for the treatment of unresectable HCC mainly come from retrospective studies that are difficult to compare because of the lack of standardized procedures. Some prognostic systems have been proposed in order to improve the selection of the patients that can benefit from treatment. While the effects in terms of tumour response are clearly documented, the results in terms of survival are still unclear. CONCLUSIONS: The real impact of TAP on survival remains to be determined in all clinical settings. The very few published prospective randomised trials are underpowered and cannot provide any definitive conclusions. Thus, there is an urgent need for prospective controlled trials in order assess the impact of TAP on survival and to compare different procedures.
Ermelinda De Maio; Francesco Fiore; Bruno Daniele; Roberto D'Angelo; Francesco Perrone; Emiddio Barletta; Rosario Vincenzo Iaffaioli; Sandro Pignata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  46     ISSN:  1040-8428     ISO Abbreviation:  Crit. Rev. Oncol. Hematol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-06     Completed Date:  2004-02-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Medical oncology B, National Cancer Institute of Naples, Via M. Semmola, 80131, Naples, Italy.
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MeSH Terms
Antineoplastic Agents / administration & dosage*
Carcinoma, Hepatocellular / drug therapy,  physiopathology,  therapy*
Chemoembolization, Therapeutic
Embolization, Therapeutic*
Hepatic Artery*
Infusions, Intra-Arterial
Liver Neoplasms / drug therapy,  physiopathology,  therapy*
Randomized Controlled Trials as Topic
Survival Analysis
Treatment Outcome
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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