Document Detail


Transcatheter Infusion of Epirubicin in Water-in-Oil-in-Water Emulsion via a Cystic Artery for the Treatment of Hepatocellular Carcinoma.
MedLine Citation:
PMID:  20859629     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSE: We have previously reported the clinical efficacy of water-in-oil-in-water (W/O/W) emulsion containing anticancer agent. The purpose of this study was to evaluate the safety and effectiveness of transcatheter arterial infusion (TAI) of W/O/W emulsion via a cystic artery for hepatocellular carcinoma (HCC).
METHODS: TAI of a W/O/W emulsion was performed at our institute in five patients with Stage III or IV HCC with blood supply from the cystic artery. In all patients, 2-12 ml W/O/W emulsion was infused via a cystic artery. Therapeutic effects and complications were evaluated in these patients.
RESULTS: Of the five patients treated, one achieved a complete response and two achieved a partial response. After treatment, acute cholecystitis or gallbladder ischemia that required treatment was not encountered in any patient.
CONCLUSIONS: W/O/W emulsion can be safely infused via a cystic artery without major complications; it is a good therapeutic option for the patients with advanced HCC fed by a cystic artery.
Authors:
I Ikushima; S Higashi; A Ishii; K Seguchi; Y Iryo; Y Ota; M Shima
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Publication Detail:
Type:  Journal Article     Date:  2010-09-23
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  34     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  802-7     Citation Subset:  IM    
Affiliation:
Department of Radiology, Miyakonojo Medical Association Hospital, 5822-3 Oiwadacho, Miyakonojo, 885-0062, Japan, iku@cap.bbiq.jp.
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