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Transcatheter Arterial Chemoembolization in Combination With High-Intensity Focused Ultrasound for Unresectable Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of the Chinese Literature.
MedLine Citation:
PMID:  21640479     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To evaluate the therapeutic effects of transcatheter arterial chemoembolization (TACE) in combination with high-intensity focused ultrasound (HIFU) for unresectable hepatocellular carcinoma (UHCC), we performed a systematic review and meta-analysis by searching the database. In nine controlled trials with a total of 736 patients, the effect of TACE plus HIFU (group A) was compared with TACE alone (group B) in treating UHCC. Outcomes mainly included tumor response and survival. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each relationship from raw study data using the fixed-effect model or the random effect model. We found that group A significantly improved the tumor response and 0.5-, 1-, 2-, and 3-year survival of patients. In conclusion, combined therapy was more therapeutically beneficial. However, considering the strength of the evidence, additional randomized controlled trials are needed before combined therapy can be recommended routinely.
Authors:
Hui Cao; Zhong Xu; Hao Long; Ling-Ling Zhang; Jun Zhang; Zhi-Ping Peng; Shao-Lin Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-1
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  -     ISSN:  1879-291X     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Radiological Medicine, Chongqing Medical University, Chongqing, PR China.
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