| Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress. | |
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MedLine Citation:
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PMID: 11334551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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8-iso-prostaglandin F(2 alpha)(8-iso-PGF(2 alpha)), a representative isoprostane, has been reported to be a reliable marker for oxidant stress in vivo. To examine if 8-iso-PGF(2 alpha)is generated in patients with acute myocardial infarction (AMI), we measured the level of immunoreactive 8-iso PGF(2 alpha)in the great cardiac vein as well as classical eicosanoids, 6-keto-prostaglandin F(1 alpha)(6-keto-PGF(1 alpha)) and thromboxane B(2)(TXB(2)) in the process of urgent coronary balloon angioplasty. Fourteen patients with anterior AMI were divided into two groups: the totally occluded (n=7) and the already perfused groups (n=7). In the former, transient elevation of 8-iso-PGF(2 alpha)was observed immediately after the angioplasty, i.e. the ratio of post-angioplasty level to pre-level was approximately 2.4 for 8-iso-PGF(2 alpha), 14 for 6-keto-PGF(1 alpha), and 5 for TXB(2). In the already perfused group, the levels of these eicosanoids were unchanged. In the totally occluded group, peak creatine phosphokinase in a peripheral vein was correlated with the level of 8-iso-PGF(2 alpha)(r(2)=0.841, P<0.01), but not with those of the other two eicosanoids. In conclusion, transcardiac 8-iso-PGF(2 alpha)generation is a reliable marker for the size of myocardium exposed to oxidant stress. |
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Authors:
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Y Kijima; K Hashimura; Y Matsu-ura; Y Kato; T Yasuda; T Ueda; Y Orita; M Fukunaga |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 64 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2001 Mar |
Date Detail:
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Created Date: 2001-05-03 Completed Date: 2001-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 161-6 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Harcourt Publishers Ltd. |
Affiliation:
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Cardiovascular Division, Ishinkai Yao General Hospital, Yao, Osaka, Japan. ykijima@yo.rim.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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biosynthesis Adult Aged Angioplasty, Transluminal, Percutaneous Coronary Creatine Kinase / metabolism Dinoprost / analogs & derivatives, biosynthesis* F2-Isoprostanes Female Humans Male Middle Aged Myocardial Infarction / metabolism* Myocardium / metabolism* Oxidative Stress Oxygen / metabolism Reperfusion Thromboxane B2 / biosynthesis Time Factors |
| Chemical | |
Reg. No./Substance:
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0/F2-Isoprostanes; 27415-26-5/8-epi-prostaglandin F2alpha; 54397-85-2/Thromboxane B2; 551-11-1/Dinoprost; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7782-44-7/Oxygen; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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