| Transcapillary forces in subcutaneous tissue of lower limbs with deep venous thrombosis. | |
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MedLine Citation:
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PMID: 3749787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Starling forces (interstitial fluid pressure, plasma- and interstitial fluid colloid osmotic pressures) were measured in the subcutaneous tissue of legs in 22 patients with deep venous thrombosis (DVT). For comparison, measurements were obtained in the contralateral leg and in healthy controls as well. Interstitial fluid pressure (Pif) was measured with the 'wick-in-needle' technique and we found a significantly higher pressure in limbs with DVT compared to contralateral limbs and controls. Interstitial fluid was collected from subcutaneous tissue with the 'wick technique'. Colloid osmotic pressure was measured in wick interstitial fluid (COPif) and plasma (COPpl) with an osmometer. A significant reduction of COPif was found in limbs with DVT compared to the contralateral side and controls. The COPpl was also significantly reduced in patients compared to controls. Saphenous vein pressure (Pv) measured at the ankle was significantly increased in the thrombosed limb compared to the contralateral. We conclude that the main cause of subcutaneous oedema in DVT of the lower limbs is increased transcapillary filtration caused by a rise in Pv. This leads to a fall in COPif and rise in Pif which act as oedema-preventing mechanisms. |
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Authors:
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E Seem; E Stranden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 46 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-10-15 Completed Date: 1986-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: NORWAY |
Other Details:
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Languages: eng Pagination: 417-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Pressure Capillaries / physiopathology* Colloids / analysis Edema / etiology, physiopathology Extracellular Space / physiology Female Humans Leg / blood supply* Male Middle Aged Osmotic Pressure Saphenous Vein / physiopathology Thrombophlebitis / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Colloids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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