Document Detail

Transcallosal inhibition in patients with callosal infarction.
MedLine Citation:
PMID:  23136342     Owner:  NLM     Status:  Publisher    
Recent studies in normal subjects suggested the callosal motor fibers pass through the posterior body of the corpus callosum (CC) but this has not been tested in patients with callosal infarction. The objective of the study is to define the pathways involved in transcallosal inhibition by examining patients with infarctions in different sub-regions of the CC. We hypothesized that patients with lesions in the posterior half of the CC would have greater reduction in transcallosal inhibition between the motor cortices. Twenty six patients with callosal infarction and 10 healthy subjects were studied. The callosal lesions were localized on sagittal MRI and were attributed to one of five segments of the CC. Transcranial magnetic stimulation was used to assess ipsilateral silent period (iSP), short (SIHI) and long latency (LIHI) interhemispheric inhibition originating from both motor cortices. The results showed that the iSP areas and durations were markedly reduced bilaterally in patients with callosal infarction compared to normal subjects. Patients with callosal infarctions also had less IHI bidirectionally compared to normal subjects. iSP areas and durations were lower in patients with lesions than patients without lesions in segments 3 (posterior midbody) of the CC. Lesion burden in the posterior half of the CC negatively correlated transcallosal inhibition measured with iSP and SIHI. Our study suggests that callosal infarction led to reduced transcallosal inhibition as measured by iSP, SIHI and LIHI. Fibers mediating transcallosal inhibition cross the CC mainly in the posterior half.
Jie-Yuan Li; Ping-Hong Lai; Robert Chen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  Journal of neurophysiology     Volume:  -     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Kaohsiung Veterans General Hospital.
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