Document Detail


Transaminitis in Duchenne's muscular dystrophy.
MedLine Citation:
PMID:  11269976     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Persistently raised transaminase levels often prompt the clinician to investigate for liver pathology. Previously, some of our patients with Duchenne's muscular dystrophy have had investigations to look for liver disorders when the alanine transaminases (ALTs) were found incidentally to be high. AIM: The objective of the study was to ascertain the levels of the transaminases in patients with Duchenne's muscular dystrophy and to see if the levels of transaminases correlated with muscle enzymes such as creatine kinase (CK). MATERIALS AND METHODS: This is a case series of 19 patients with Duchenne's muscular dystrophy. Alanine and aspartate transaminase (AST) levels and CK levels were measured in the serum of the patients. RESULTS: In this series, ALT and AST levels were all found to be raised significantly in patients with biopsy-proven Duchenne's muscular dystrophy and Becker's muscular dystrophy. Alanine transaminase, in particular, was raised to a mean of 356 mmol/L, 9 times above the mean for normal. There was also good correlation between ALT and CK levels with a correlation coefficient of r = 0.80 and P value 0.01. Similar to CK, the transaminase levels were inversely proportional to mobility and to age. CONCLUSION: The presence of hypertransaminasemia in patients with muscular dystrophy should be attributed to muscle breakdown rather than to liver pathology and such patients should not be over-investigated for liver disease. In the absence of liver pathology, raised transaminases may be an early sign of occult muscular dystrophy and such patients should have CK levels checked to look for evidence of muscular dystrophy.
Authors:
S K Tay; H T Ong; P S Low
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  29     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-03-28     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  719-22     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / analysis,  metabolism*
Aspartate Aminotransferases / analysis,  metabolism*
Biological Markers / analysis
Child
Child, Preschool
Creatine Kinase / analysis,  metabolism*
Female
Humans
Male
Muscular Dystrophy, Duchenne
Probability
Prognosis
Prospective Studies
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Biological Markers; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase

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