| Transactivating function of integrated hepatitis B virus. | |
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MedLine Citation:
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PMID: 8280135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HBV DNAs are often found in integrated forms in human hepatocellular carcinoma (HCC). Discovery of a transactivation function coded by a limited region of the HBV genome has promoted us to survey our collection of HBV integrants with flanking cellular sequences, asking whether they might exhibit a transactivation function. In transient cotransfection assays using the HepG2 cell line, six out of the twelve integrants showed transactivation effects on the expression of cellular genes such as c-fos. These results strongly demonstrate that the transactivating effects of integrated HBV DNA are widely distributed, and some of these effects might be correlated to hepatocarcinogenesis. |
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Authors:
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S Yamamoto; E Mita; H Nakatake; M Takimoto; R Koshy; K Matsubara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 197 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-02-10 Completed Date: 1994-02-10 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1209-15 Citation Subset: IM |
Affiliation:
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Institute for Molecular and Cellular Biology, Osaka University, Suita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Hepatocellular
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chemistry,
microbiology Cell Line Chloramphenicol O-Acetyltransferase / biosynthesis, metabolism DNA, Neoplasm / chemistry DNA, Viral / isolation & purification, metabolism* Hepatitis B virus / genetics* Humans Liver Neoplasms / chemistry, microbiology Restriction Mapping Transcriptional Activation* Transfection Tumor Cells, Cultured Virus Integration* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/DNA, Viral; EC 2.3.1.28/Chloramphenicol O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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