Document Detail


Transabdominal ultrasonographic evaluation of endometrial thickness in clomiphene citrate-stimulated cycles in relation to conception.
MedLine Citation:
PMID:  8132788     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possible antiestrogenic effect of clomiphene citrate on endometrial growth was assessed by serial transabdominal ultrasonographic measurements in 46 women with unexplained infertility. A significantly higher (p < 0.05) rate of endometrial growth was observed in the 8 women who conceived compared with the 38 women who failed to conceive. A thicker endometrium (4.6 +/- 0.3 mm) was observed from the third day before ovulation as well as a higher average growth rate in the three days prior to ovulation (0.7 +/- 0.1 mm/day) in the group that achieved pregnancy compared to a lower endometrium (2.1 +/- 0.2 mm) from the third day before ovulation and a slower growth rate in the three days prior to ovulation (0.2 +/- 0.0 mm/day) in the group that did not achieve pregnancy (p < 0.05). These data suggest that clomiphene citrate may exert an antiestrogenic effect on the endometrium, and thus interfere with implantation.
Authors:
I Wolman; J Sagi; D Pauzner; I Yovel; D S Seidman; M P David
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical ultrasound : JCU     Volume:  22     ISSN:  0091-2751     ISO Abbreviation:  J Clin Ultrasound     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-20     Completed Date:  1994-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401663     Medline TA:  J Clin Ultrasound     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology B, Serlin Maternity Hospital, Tel-Aviv, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Clomiphene / pharmacology*
Embryo Implantation / drug effects*
Endometrium / drug effects*,  ultrasonography*
Female
Fertilization / drug effects,  physiology*
Humans
Menstrual Cycle / drug effects
Chemical
Reg. No./Substance:
911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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