Document Detail


Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks.
MedLine Citation:
PMID:  14564111     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the efficacy of transabdominal amnioinfusion on feto-neonatal and maternal morbidity and feto-neonatal mortality. METHODS: We studied 71 patients with preterm premature rupture of membranes (pPROM) at <26 weeks of gestational age. Thirty-four patients were managed expectantly and 37 underwent serial transabdominal amnioinfusion with saline every 7 days in case of persistent oligohydramnios. RESULTS: Latency period pPROM delivery, week of delivery (26.0 vs. 22.4, p<0.001), neonatal weight (922 vs. 602, p<0.01) and the percentage of intrauterine fetal survival were higher in treated than in control groups (64.8 vs. 32.3%, p<0.01). In amnioinfusion-treated patients, we did not note a higher rate of complications from infection during both pregnancy and puerperium. In the amnioinfusion group, fluid loss within 6 h after infusion is the main variable in predicting pulmonary hypoplasia and neonatal survival. CONCLUSIONS: Our data suggest that amnioinfusion seems to be a low fetal and maternal risk technique that modifies the natural history of pPROM, improving fetal intrauterine stay and survival.
Authors:
Marco De Santis; Maria Scavo; Giuseppe Noia; Lucia Masini; Fiammetta Piersigilli; Costantino Romagnoli; Alessandro Caruso
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  18     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-10-17     Completed Date:  2004-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  412-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy. marcodesantis@rm.unicatt.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Amnion / drug effects*,  microbiology,  ultrasonography
Chi-Square Distribution
Female
Fetal Membranes, Premature Rupture / drug therapy*,  microbiology,  ultrasonography
Gestational Age*
Humans
Infant, Newborn
Infusions, Parenteral / methods
Male
Oligohydramnios / drug therapy*,  microbiology,  ultrasonography
Pregnancy
Prospective Studies
Sodium Chloride / administration & dosage,  therapeutic use
Statistics, Nonparametric
Survival Analysis
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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