| Transabdominal amnioinfusion treatment of severe oligohydramnios in preterm premature rupture of membranes at less than 26 gestational weeks. | |
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MedLine Citation:
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PMID: 14564111 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy of transabdominal amnioinfusion on feto-neonatal and maternal morbidity and feto-neonatal mortality. METHODS: We studied 71 patients with preterm premature rupture of membranes (pPROM) at <26 weeks of gestational age. Thirty-four patients were managed expectantly and 37 underwent serial transabdominal amnioinfusion with saline every 7 days in case of persistent oligohydramnios. RESULTS: Latency period pPROM delivery, week of delivery (26.0 vs. 22.4, p<0.001), neonatal weight (922 vs. 602, p<0.01) and the percentage of intrauterine fetal survival were higher in treated than in control groups (64.8 vs. 32.3%, p<0.01). In amnioinfusion-treated patients, we did not note a higher rate of complications from infection during both pregnancy and puerperium. In the amnioinfusion group, fluid loss within 6 h after infusion is the main variable in predicting pulmonary hypoplasia and neonatal survival. CONCLUSIONS: Our data suggest that amnioinfusion seems to be a low fetal and maternal risk technique that modifies the natural history of pPROM, improving fetal intrauterine stay and survival. |
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Authors:
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Marco De Santis; Maria Scavo; Giuseppe Noia; Lucia Masini; Fiammetta Piersigilli; Costantino Romagnoli; Alessandro Caruso |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 18 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-10-17 Completed Date: 2004-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 412-7 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Rome, Italy. marcodesantis@rm.unicatt.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amnion / drug effects*, microbiology, ultrasonography Chi-Square Distribution Female Fetal Membranes, Premature Rupture / drug therapy*, microbiology, ultrasonography Gestational Age* Humans Infant, Newborn Infusions, Parenteral / methods Male Oligohydramnios / drug therapy*, microbiology, ultrasonography Pregnancy Prospective Studies Sodium Chloride / administration & dosage, therapeutic use Statistics, Nonparametric Survival Analysis |
| Chemical | |
Reg. No./Substance:
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7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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