Document Detail

Trans-thoracic fluid shifts and endocrine responses to 6 degrees head-down tilt.
MedLine Citation:
PMID:  1837213     Owner:  NLM     Status:  MEDLINE    
A tomographic method of measuring electrical impedance known as Applied Potential Tomography (APT) has been used to image the impedance changes within the thoraxes of 8 healthy volunteers (4 male, 4 female) during 4-h periods of 6 degrees head-down tilt (HDT). A large decrease in impedance, reflecting an increase in thoracic fluid, was apparent within 1 min of tilting, peaked after 45 min, and was maintained throughout, although during the 4 h there was an 8% return towards baseline resistivity. Resistivity changes were most obvious in the region of the lungs. Simultaneous measurements of the key fluid regulating hormones revealed a significant increase in atrial natriuretic peptide (ANP) and a significant decrease in angiotensin II (AII) and aldosterone. There was no significant difference in plasma antidiuretic hormone level. These results illustrate the dynamic nature of fluid shifts during HDT, the spatial distribution of the fluid within the thorax and the associated endocrine responses.
D Grundy; K Reid; F J McArdle; B H Brown; D C Barber; C F Deacon; I W Henderson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  62     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-02-13     Completed Date:  1992-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  923-9     Citation Subset:  IM; S    
Department of Biomedical Science, University of Sheffield, England.
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MeSH Terms
Aldosterone / blood*
Angiotensin II / blood*
Atrial Natriuretic Factor / blood*
Blood Volume / physiology
Body Fluids / physiology*
Electric Conductivity
Heart Rate
Lung / physiology
Sex Factors
Space Flight
Thorax / physiology*
Time Factors
Tomography / methods
Reg. No./Substance:
11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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