Document Detail

Trans-sphenoidal microsurgical treatment of Nelson's syndrome.
MedLine Citation:
PMID:  2993956     Owner:  NLM     Status:  MEDLINE    
Clinical features and the operative results in the author's personal series of ten cases with Nelson's syndrome are presented. There were nine females and one male patient with ages ranging from 20 to 44 years (mean 36 y). All patients presented with typical hyperpigmentation of the skin and had abnormally raised plasma ACTH levels. X-ray polytomography detected sellar abnormalities in 80% of the cases. Computerized tomography was positive for pituitary tumour in three patients. Trans-sphenoidal microsurgical removal of Nelson's ACTH adenomas were successful in seven of ten patients. The operative technique of radical-selective resection to achieve endocrinological cure is described. Pertinent literature is reviewed and the incidence of Nelson's syndrome, an issue of controversies regarding the pathogenesis, and the management of Nelson's adenomas are discussed.
T Fukushima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgical review     Volume:  8     ISSN:  0344-5607     ISO Abbreviation:  Neurosurg Rev     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-22     Completed Date:  1985-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7908181     Medline TA:  Neurosurg Rev     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  185-94     Citation Subset:  IM    
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MeSH Terms
Adenoma / surgery*
Adenoma, Acidophil / surgery
Adenoma, Basophil / surgery
Adenoma, Chromophobe / surgery
Adrenocorticotropic Hormone / blood
Nelson Syndrome / surgery*
Pituitary Neoplasms / surgery*
Skull / radiography
Sphenoid Sinus / surgery
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

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