| Trans-sphenoidal microsurgical treatment of Nelson's syndrome. | |
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MedLine Citation:
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PMID: 2993956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical features and the operative results in the author's personal series of ten cases with Nelson's syndrome are presented. There were nine females and one male patient with ages ranging from 20 to 44 years (mean 36 y). All patients presented with typical hyperpigmentation of the skin and had abnormally raised plasma ACTH levels. X-ray polytomography detected sellar abnormalities in 80% of the cases. Computerized tomography was positive for pituitary tumour in three patients. Trans-sphenoidal microsurgical removal of Nelson's ACTH adenomas were successful in seven of ten patients. The operative technique of radical-selective resection to achieve endocrinological cure is described. Pertinent literature is reviewed and the incidence of Nelson's syndrome, an issue of controversies regarding the pathogenesis, and the management of Nelson's adenomas are discussed. |
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Authors:
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T Fukushima |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosurgical review Volume: 8 ISSN: 0344-5607 ISO Abbreviation: Neurosurg Rev Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-22 Completed Date: 1985-10-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7908181 Medline TA: Neurosurg Rev Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 185-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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surgery* Adenoma, Acidophil / surgery Adenoma, Basophil / surgery Adenoma, Chromophobe / surgery Adrenocorticotropic Hormone / blood Adult Female Humans Male Methods Microsurgery* Nelson Syndrome / surgery* Pituitary Neoplasms / surgery* Skull / radiography Sphenoid Sinus / surgery |
| Chemical | |
Reg. No./Substance:
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9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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