Document Detail

Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.
MedLine Citation:
PMID:  22902718     Owner:  NLM     Status:  MEDLINE    
Cell migration is fundamental to organogenesis. During development, the enteric neural crest cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize the entire length of the gut, which undergoes substantial growth and morphological rearrangement. How ENCCs adapt to such changes during migration, however, is not fully understood. Using time-lapse imaging analyses of mouse ENCCs, we show that a population of ENCCs crosses from the midgut to the hindgut via the mesentery during a developmental time period in which these gut regions are transiently juxtaposed, and that such 'trans-mesenteric' ENCCs constitute a large part of the hindgut ENS. This migratory process requires GDNF signaling, and evidence suggests that impaired trans-mesenteric migration of ENCCs may underlie the pathogenesis of Hirschsprung disease (intestinal aganglionosis). The discovery of this trans-mesenteric ENCC population provides a basis for improving our understanding of ENS development and pathogenesis.
Chihiro Nishiyama; Toshihiro Uesaka; Takayuki Manabe; Yohei Yonekura; Takashi Nagasawa; Donald F Newgreen; Heather M Young; Hideki Enomoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-19
Journal Detail:
Title:  Nature neuroscience     Volume:  15     ISSN:  1546-1726     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-30     Completed Date:  2012-11-05     Revised Date:  2012-12-03    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1211-8     Citation Subset:  IM    
Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan.
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MeSH Terms
Cell Count
Cell Movement
Colon / embryology*,  innervation*
Enteric Nervous System / embryology*,  physiology*
Glial Cell Line-Derived Neurotrophic Factor / biosynthesis,  genetics
Glial Cell Line-Derived Neurotrophic Factor Receptors / genetics
Hirschsprung Disease / genetics,  pathology
Magnetic Resonance Imaging
Mesentery / cytology,  embryology*,  innervation
Mice, Inbred C57BL
Mice, Transgenic
Neural Crest / cytology,  physiology*
Organ Culture Techniques
Polymerase Chain Reaction
Reg. No./Substance:
0/Gfra1 protein, mouse; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Glial Cell Line-Derived Neurotrophic Factor Receptors
Comment In:
Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):559   [PMID:  22945444 ]

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