| Trans fatty acids: chemical synthesis of eicosapentaenoic acid isomers and detection in rats fed a deodorized fish oil diet. | |
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MedLine Citation:
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PMID: 22283477 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Eicosapentaenoic acid (EPA) is a polyunsaturated fatty acid present in fish oils used for omega-3 enriched diets. The natural cis double bond geometry can be transformed to the trans configuration during the deodorization process utilized in food industry. The analytical discrimination of the possible five mono-trans regioisomers represents a limiting step for recognition and structure-activity relationship in connection with the harmful effects of trans fatty acids in health. We carried out a dual synthetic strategy, providing a new access to mono-trans EPA isomers and valuable information on GC and NMR characteristics for further applications in metabolomics and lipidomics. This small library was used as analytical reference for the isomer determination in deodorized fish oils and the follow-up of rats fed fish oil diets, evidencing for the first time that mono-trans EPA isomers are incorporated in liver mito-chondria membranes after dietary intake. |
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Authors:
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Carla Ferreri; Stanislav Anatol Evich Grabovskiy; Manar Aoun; Michele Melchiorre; Natalia Kabal'nova; Christine Feillet-Coudray; Gilles Fouret; Charles Coudray; Chryssostomos Chatgilialoglu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-27 |
Journal Detail:
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Title: Chemical research in toxicology Volume: - ISSN: 1520-5010 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807448 Medline TA: Chem Res Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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