Document Detail


Trans fatty acids and birth outcome: some first results of the MEFAB and ABCD cohorts.
MedLine Citation:
PMID:  16713386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using data from two longitudinal pregnancy and birth cohorts in the Netherlands, the potential influence of trans fatty acids (TFA) on fetal development was investigated by multiple regression analysis. After adjustment for a large number of potential confounders, birth length (BL) and head circumference (HC) were significantly and negatively related to the C18:1trans concentration in phospholipids isolated from umbilical plasma (HC), umbilical arterial walls (HC and BL), or umbilical venous walls (BL). A significant and negative relationship was also observed between birth weight and the C18:1trans concentration in maternal plasma phospholipids at early pregnancy, but this attenuated upon correction for potential confounders. These results indicate that TFA may compromise fetal development.
Authors:
Gerard Hornstra; Manon van Eijsden; Chantal Dirix; Gouke Bonsel
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-05-19
Journal Detail:
Title:  Atherosclerosis. Supplements     Volume:  7     ISSN:  1567-5688     ISO Abbreviation:  Atheroscler Suppl     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-11-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973461     Medline TA:  Atheroscler Suppl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
Affiliation:
Maastricht University, The Netherlands. G.Hornstra@Nutrisearch.nl
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MeSH Terms
Descriptor/Qualifier:
Birth Weight*
Female
Gestational Age*
Humans
Longitudinal Studies
Maternal-Fetal Exchange
Netherlands
Pregnancy / blood*
Pregnancy Outcome
Trans Fatty Acids / metabolism*
Umbilical Arteries / metabolism
Chemical
Reg. No./Substance:
0/Trans Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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