| Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. | |
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MedLine Citation:
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PMID: 17234723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have examined the role of higher trans-fatty acid consumption on prostate cancer risk, but the results remain unclear. Any potential association may be modified by variants in genes involved with immune and inflammatory responses. To investigate this, we undertook a case-control study (N = 1012) of the association between trans-fatty acid intake and advanced prostate cancer, and evaluated whether this effect was modified by a functional polymorphism in the RNASEL gene (R462Q). Among Caucasians (N = 834), we observed that each type of trans-fatty acid and total trans-fatty acid intake showed a statistically significant positive association with prostate cancer, but only weakly increased risk for the isomers of cis-fatty acids. Compared with the lowest quartile of total trans-fatty acid consumption, the higher quartiles gave odds ratios (ORs) equal to 1.58 [95% confidence interval (CI): 1.00, 2.48], 1.95 (95% CI: 1.20, 3.19) and 2.77 (95% CI: 1.60, 4.79) (P-trend = 0.0003); this effect was modified by the RNASEL R462Q polymorphism (P(interaction) = 0.01). Among men with the QQ/RQ genotype, the association between total trans-fatty acid intake and prostate cancer was substantially stronger [ORs of higher quartiles equal to 2.93 (95% CI: 1.62, 5.30), 3.13 (95% CI: 1.64, 5.98) and 4.80 (95% CI: 2.29, 10.08), respectively]. For men with the RR genotype, total trans-fatty acid intake was not associated with disease. This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q. |
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Authors:
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Xin Liu; Fredrick R Schumacher; Sarah J Plummer; Eric Jorgenson; Graham Casey; John S Witte |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-01-18 |
Journal Detail:
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Title: Carcinogenesis Volume: 28 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-04 Completed Date: 2007-08-07 Revised Date: 2011-06-17 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: England |
Other Details:
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Languages: eng Pagination: 1232-6 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA 94143-0794, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amino Acid Substitution* / genetics Arginine / genetics Case-Control Studies Dietary Fats, Unsaturated / adverse effects*, metabolism Endoribonucleases / genetics, physiology* Glutamine / genetics Humans Male Prostatic Neoplasms / etiology*, metabolism Risk Factors Trans Fatty Acids / administration & dosage*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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CA88164/CA/NCI NIH HHS; CA94211/CA/NCI NIH HHS; CA98683/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Trans Fatty Acids; 56-85-9/Glutamine; 74-79-3/Arginine; EC 3.1.-/Endoribonucleases; EC 3.1.26.-/2-5A-dependent ribonuclease |
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