Document Detail

Tranexamic acid and upper gastrointestinal haemorrhage--a double-blind trial.
MedLine Citation:
PMID:  789186     Owner:  NLM     Status:  MEDLINE    
The efficacy of antifibrinolytic therapy in the management of acute upper gastrointestinal haemorrhage has been investigated in a double-blind clinical trial. Two-hundred patients were studied using tranexamic acid, a potent antifibrinolytic agent. Of these, 103 were in the treatment group and 97 in the control group. Patients were analysed to determine severity of initial blood loss, transfusion requirements, together with the incidence of recurrent bleeding, surgical intervention, and death. Final diagnosis as to the site of bleeding was arrived at using endoscopy, barium studies, and the findings at operation and necropsy. The groups were well matched as regards severity of initial haemorrhage, age, sex, aetiological diagnosis, and precipitating factors. A significant difference was observed in the requirement for surgical intervention to control continuing or recurrent haemorrhage. Twenty-three of 97 in the control group and seven of 103 in the treatment group required surgery. There appeared to be a reduction in the transfusion rate after the first three days of hospitalization in the treatment group. There were no significant differences in mortality or in side-effects between the two groups.
J C Biggs; T B Hugh; A J Dodds
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Gut     Volume:  17     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation Tests
Blood Transfusion
Clinical Trials as Topic
Cyclohexanecarboxylic Acids / therapeutic use*
Esophageal and Gastric Varices / drug therapy
Esophagitis / complications
Gastrointestinal Hemorrhage / drug therapy*,  surgery
Middle Aged
Peptic Ulcer Hemorrhage / drug therapy
Tranexamic Acid / therapeutic use*
Reg. No./Substance:
0/Cyclohexanecarboxylic Acids; 0/Placebos; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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