| Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting. | |
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MedLine Citation:
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PMID: 12813384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the ability of tranexamic acid, compared with an untreated control group, to decrease bleeding and transfusion requirements in patients undergoing coronary artery bypass grafting on the beating heart. METHODS: Forty-nine randomly selected patients were enrolled to elective coronary artery bypass grafting without the use of cardiopulmonary bypass. Of these, 23 received tranexamic acid (bolus of 1 g before surgical incision, followed by infusion 200 mg/hour during surgery) and 26 patients were enrolled into a control group. Preoperative hematological variables, postoperative blood loss at 4 and 24 hours, transfusion requirements of packed red blood cells,and postoperative thrombotic events such as a myocardial infarction, stroke and pulmonary embolism were recorded. RESULTS: The two groups were similar in terms of patients' characteristics. Postoperative bleeding was significantly lower in the tranexamic acid group compared with the control group (median [25th-75th percentiles]): 115 [92-148] vs 230 [170-260] mL at 4 hours, p<0.001; 420 [330-523] vs 550 [500-650] mL at 24 hours, p<0.01). Transfusion requirements were lower in the tranexamic acid group compared with the control group (RBC 9% vs 28%), but the difference was not statistically significant. Treatment with tranexamic acid was not associated with a higher incidence of myocardial ischemia or other thrombotic events. CONCLUSION: Tranexamic acid reduces postoperative blood loss after coronary artery bypass grafting on the beating heart. Evaluation of transfusion requirements warrants further study. |
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Authors:
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M Jares; T Vanek; Z Straka; P Brucek |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of cardiovascular surgery Volume: 44 ISSN: 0021-9509 ISO Abbreviation: J Cardiovasc Surg (Torino) Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-06-18 Completed Date: 2003-08-18 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0066127 Medline TA: J Cardiovasc Surg (Torino) Country: Italy |
Other Details:
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Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, 3rd Medical School of Charles University, Kralovske Vinohrady University Hospital, Prague, Czech Republic. martin.jares@gmx.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antifibrinolytic Agents
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therapeutic use* Blood Loss, Surgical / prevention & control* Coronary Artery Bypass* / methods Female Humans Male Prospective Studies Tranexamic Acid / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antifibrinolytic Agents; 1197-18-8/Tranexamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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