Document Detail

Tranexamic acid mouthwash--a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions.
MedLine Citation:
PMID:  14759109     Owner:  NLM     Status:  MEDLINE    
This prospective randomized study analyses the use of a prescribed 4.8% tranexamic acid post-operative mouthwash over 2 days vs 5 days to prevent bleeding in patients taking warfarin who require dental extractions. Eighty-five patients therapeutically anticoagulated with warfarin for various conditions, ranging in age from 21 to 86 years and requiring dental extractions, were randomly divided into two groups. Group A postoperatively received a 4.8% tranexamic acid mouthwash to be used over a 2-day period. Group B received the same mouthwash and instructions postoperatively, to be taken over 5 days. All procedures were performed on an ambulatory basis under local anaesthetic by the same surgeon. Patients were reviewed 1, 3, and 7 days postoperatively to assess bleeding. Eighty-two of the 85 patients encountered no postoperative problems. Two patients in group A and one in group B had minor postoperative bleeds that required minor ambulatory intervention to control. This study shows that a 2-day postoperative course of a 4.8% tranexamic acid mouthwash is as equally effective as a 5-day course in controlling haemostasis post-dental extractions in patient's anticoagulated with warfarin.
G Carter; A Goss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  32     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-02-04     Completed Date:  2004-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  504-7     Citation Subset:  D; IM    
Oral and Maxillofacial Surgery Unit, University of Adelaide, Adelaide, South Australia.
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MeSH Terms
Administration, Topical
Anticoagulants / adverse effects
Antifibrinolytic Agents / administration & dosage*
Dental Care for Chronically Ill*
Middle Aged
Mouthwashes / administration & dosage*
Oral Hemorrhage / etiology,  prevention & control*
Postoperative Hemorrhage / etiology,  prevention & control*
Prospective Studies
Single-Blind Method
Time Factors
Tooth Extraction
Tranexamic Acid / administration & dosage*
Warfarin / adverse effects
Reg. No./Substance:
0/Anticoagulants; 0/Antifibrinolytic Agents; 0/Mouthwashes; 1197-18-8/Tranexamic Acid; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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