Document Detail

Tranexamic acid in the treatment of pediatric traumatic hyphema.
MedLine Citation:
PMID:  18711456     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was undertaken to determine whether a difference exists in treatment outcome between patients treated with tranexamic acid (TEA) plus topical steroids and those treated with topical steroids alone. METHODS: A retrospective cohort study was conducted to compare treatment results for children with traumatic hyphema treated with TEA and topical steroids versus topical steroids alone. Patients were identified from a chart review of the Children's Hospital of Eastern Ontario eye clinic and the Queen's Department of Ophthalmology emergency eye clinic for charts coded "traumatic hyphema." The primary outcomes measured included visual acuity, rebleed rate, intraocular pressure, and time to hyphema resolution. Covariates were hyphema grade, the need for medications to lower intraocular pressure, and the presence of associated ocular traumatic complications. Analysis was performed with both bivariate analysis and multivariate models. RESULTS: Two hundred and fifteen patients with traumatic hyphema were included in our study. One hundred and thirty-seven patients (63.1%) received TEA plus topical steroids, and the remaining 78 patients received topical steroids alone. There was no significant difference in rebleed rate between the TEA plus topical steroid group (1.6%) and the steroid-alone group (2.6%, p = 0.60). INTERPRETATION: Patients with traumatic hyphema treated with TEA plus topical steroids did not have a significantly lower incidence of rebleed than those treated with topical steroids alone.
David A Albiani; William G Hodge; Y Irene Pan; Todd E Urton; William N Clarke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie     Volume:  43     ISSN:  0008-4182     ISO Abbreviation:  Can. J. Ophthalmol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045312     Medline TA:  Can J Ophthalmol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  428-31     Citation Subset:  IM    
University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
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MeSH Terms
Antifibrinolytic Agents / therapeutic use*
Drug Therapy, Combination
Eye Injuries / complications,  drug therapy*
Glucocorticoids / therapeutic use
Hyphema / drug therapy*,  etiology
Intraocular Pressure / physiology
Retrospective Studies
Tranexamic Acid / therapeutic use*
Treatment Outcome
Visual Acuity / physiology
Wounds, Nonpenetrating / complications,  drug therapy*
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Glucocorticoids; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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