Document Detail

Tranexamic acid in the prevention of periventricular haemorrhage.
MedLine Citation:
PMID:  6383225     Owner:  NLM     Status:  MEDLINE    
Increased fibrinolytic activity in the ganglionic eminence of the preterm human brain has been proposed as a factor in the aetiology of periventricular haemorrhage. The effect of tranexamic acid in preventing periventricular haemorrhage was evaluated in 100 infants in a double blind, randomised controlled trial. Haemorrhages developed in 22 infants who received tranexamic acid and in 20 of those who received placebo. A significant reduction in fibrin degradation products in treated infants was seen. Our study suggests that excessive fibrinolytic activity is not an important factor in the aetiology of periventricular haemorrhage and that treatment with tranexamic acid will not prevent its occurrence.
O J Hensey; M E Morgan; R W Cooke
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  59     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-26     Completed Date:  1984-09-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  719-21     Citation Subset:  AIM; IM    
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MeSH Terms
Cerebral Hemorrhage / blood,  prevention & control*
Cerebral Ventricles*
Clinical Trials as Topic
Cyclohexanecarboxylic Acids / therapeutic use*
Double-Blind Method
Fibrin Fibrinogen Degradation Products / analysis
Infant, Newborn
Infant, Premature, Diseases / prevention & control*
Random Allocation
Tranexamic Acid / therapeutic use*
Reg. No./Substance:
0/Cyclohexanecarboxylic Acids; 0/Fibrin Fibrinogen Degradation Products; 1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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