Document Detail

Tranexamic acid can treat ultraviolet radiation-induced pigmentation in guinea pigs.
MedLine Citation:
PMID:  20400389     Owner:  NLM     Status:  MEDLINE    
Exposure of human skin to ultraviolet (UV) radiation causes erythema and pigmentation. Guinea pigs are recognized as having pigmentation similar to that of humans, after exposure to UV radiation. Recently, the curative effect of oral treatment of tranexamic acid in skin pigmentation was confirmed by many doctors in China. Our aim was to investigate the effects of tranexamic acid on pigmentation in the skin of guinea pigs exposed to UV irradiation and its possible mechanism. Guinea pigs were exposed to UVB radiation (60 min per day) for 30 days, skin pigmentation was clearly observed after that. 30 days later, tranexamic acid (5 mg/mL) was intradermally injected into the exposed regions every day after radiation to prevent or inhibit the pigmentation process. After 30 days the skin was removed and stained by HMB45 immunohistochemistry and the Masson Fontana-Ponceau method. HMB45 positive expression melanocytes in the basal layer of UV-exposed epidermis showed no significant differences in the regions to which tranexamic acid solutions had been applied compared with the control. But the melanin content was significantly reduced. We concluded that tranexamic acid has no effect on the number of melanocytes, it is likely that it affects the function of melanocytes, to inhibit the melanin expression in order to lighten moth patches.
Daning Li; Yu Shi; Meiyun Li; Jinfen Liu; Xinqing Feng
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-19
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  20     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-05-20     Completed Date:  2010-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  289-92     Citation Subset:  IM    
Dermatology Department, Xuhui Central Hospital, Shanghai, 200031, China.
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MeSH Terms
Antifibrinolytic Agents / administration & dosage,  therapeutic use*
Antigens, Neoplasm / analysis
Disease Models, Animal
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Follow-Up Studies
Guinea Pigs
Injections, Intradermal
Neoplasm Proteins / analysis
Pigmentation Disorders / drug therapy*,  etiology,  pathology
Skin / metabolism,  pathology,  radiation effects
Skin Pigmentation / drug effects,  radiation effects*
Tranexamic Acid / administration & dosage,  therapeutic use*
Treatment Outcome
Ultraviolet Rays / adverse effects*
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Antigens, Neoplasm; 0/Neoplasm Proteins; 0/melanoma-specific antigens; 1197-18-8/Tranexamic Acid

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