Document Detail

Tranexamic acid: an alternative to aprotinin as antifibrinolytic therapy in pediatric congenital heart surgery.
MedLine Citation:
PMID:  20832330     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There has been concern about the usage of aprotinin, an antifibrinolytic drug that was often used in pediatric cardiac surgery until 2006. At our center, these concerns led to the replacement of aprotinin with tranexamic acid for antifibrinolytic treatment.
METHODS: In this retrospective observational study, two groups of pediatric patients were studied during two different periods, receiving either aprotinin (n=70) or tranexamic acid (n=70) upon cardiac surgery. Data were collected from children with cyanotic heart defects, children who weighed less than 10 kg, and children who underwent re-operation.
RESULTS: There was no difference in terms of blood loss or amount of erythrocyte concentrates and fresh frozen plasma transfused. Only the intraoperative amount of platelet concentrate received by children in the tranexamic acid group was 29 ml (p=0.013) higher. There was no significant difference in the length of stay at the intensive care unit, in renal function values, or in the rate of rethoracotomy.
CONCLUSIONS: The results of this study suggest that tranexamic acid represents an adequate alternative to aprotinin in congenital cardiac surgery.
Ehrenfried Schindler; Joachim Photiadis; Nicodème Sinzobahamvya; Albert Döres; Boulos Asfour; Victor Hraska
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-09-15
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  39     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-07-20     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  495-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
Pediatric Anesthesiology, German Pediatric Heart Center, Sankt Augustin, Germany.
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MeSH Terms
Antifibrinolytic Agents / therapeutic use*
Aprotinin / therapeutic use*
Blood Loss, Surgical*
Blood Transfusion / statistics & numerical data
Cardiac Surgical Procedures*
Child, Preschool
Erythrocyte Transfusion / statistics & numerical data
Heart Defects, Congenital / surgery*
Retrospective Studies
Tranexamic Acid / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antifibrinolytic Agents; 1197-18-8/Tranexamic Acid; 9087-70-1/Aprotinin
Comment In:
Eur J Cardiothorac Surg. 2012 Feb;41(2):466; author reply 466-7

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