Document Detail


Tramtrack regulates different morphogenetic events during Drosophila tracheal development.
MedLine Citation:
PMID:  17881489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tramtrack (Ttk) is a widely expressed transcription factor, the function of which has been analysed in different adult and embryonic tissues in Drosophila. So far, the described roles of Ttk have been mainly related to cell fate specification, cell proliferation and cell cycle regulation. Using the tracheal system of Drosophila as a morphogenetic model, we have undertaken a detailed analysis of Ttk function. Ttk is autonomously and non-autonomously required during embryonic tracheal formation. Remarkably, besides a role in the specification of different tracheal cell identities, we have found that Ttk is directly involved and required for different cellular responses and morphogenetic events. In particular, Ttk appears to be a new positive regulator of tracheal cell intercalation. Analysis of this process in ttk mutants has unveiled cell shape changes as a key requirement for intercalation and has identified Ttk as a novel regulator of its progression. Moreover, we define Ttk as the first identified regulator of intracellular lumen formation and show that it is autonomously involved in the control of tracheal tube size by regulating septate junction activity and cuticle formation. In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development.
Authors:
Sofia J Araújo; Carolina Cela; Marta Llimargas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-19
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  134     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3665-76     Citation Subset:  IM    
Affiliation:
Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Parc Cientific de Barcelona, Josep Samitier 1-5, 08028 Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adherens Junctions / metabolism
Animals
Cell Fusion
Cell Shape
Drosophila Proteins / genetics,  metabolism*
Drosophila melanogaster* / anatomy & histology,  embryology,  genetics,  metabolism
Embryo, Nonmammalian* / anatomy & histology,  physiology
Morphogenesis*
Receptors, Notch / genetics,  metabolism
Repressor Proteins / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Receptors, Notch; 0/Repressor Proteins; 0/notch protein, Drosophila; 0/ttk protein, Drosophila

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