Document Detail

Tramadol-warfarin interaction.
MedLine Citation:
PMID:  9692666     Owner:  NLM     Status:  MEDLINE    
A 61-year-old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily stopping warfarin. The mechanism for this interaction is unknown. Practitioners should be aware of the possibility of such a interaction and exercise caution when tramadol is prescribed for a patient receiving warfarin.
J R Sabbe; P J Sims; M H Sims
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  18     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1998 Jul-Aug
Date Detail:
Created Date:  1998-10-07     Completed Date:  1998-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  871-3     Citation Subset:  IM    
Samford University McWhorter School of Pharmacy, Department of Pharmacy Practice, Birmingham, Alabama, USA.
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MeSH Terms
Analgesics, Opioid / adverse effects*,  therapeutic use
Anticoagulants / adverse effects*,  therapeutic use
Drug Interactions
Ecchymosis / chemically induced
Middle Aged
Tramadol / adverse effects*,  therapeutic use
Warfarin / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anticoagulants; 27203-92-5/Tramadol; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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