| Tramadol-warfarin interaction. | |
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MedLine Citation:
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PMID: 9692666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 61-year-old women receiving warfarin after mitral valve replacement experienced extensive ecchymoses after starting tramadol therapy. Laboratory values revealed critical elevations of prothrombin time and international normalized ratio. The patient's coagulation values returned to acceptable levels after discontinuing tramadol and temporarily stopping warfarin. The mechanism for this interaction is unknown. Practitioners should be aware of the possibility of such a interaction and exercise caution when tramadol is prescribed for a patient receiving warfarin. |
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Authors:
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J R Sabbe; P J Sims; M H Sims |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 18 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1998 Jul-Aug |
Date Detail:
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Created Date: 1998-10-07 Completed Date: 1998-10-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 871-3 Citation Subset: IM |
Affiliation:
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Samford University McWhorter School of Pharmacy, Department of Pharmacy Practice, Birmingham, Alabama, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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adverse effects*,
therapeutic use Anticoagulants / adverse effects*, therapeutic use Drug Interactions Ecchymosis / chemically induced Female Humans Middle Aged Tramadol / adverse effects*, therapeutic use Warfarin / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anticoagulants; 27203-92-5/Tramadol; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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