| Tramadol and hypoglycaemia: comparison with other step 2 analgesic drugs. | |
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MedLine Citation:
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PMID: 22943675 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: The risk of hypoglycaemia with tramadol (TRM) is not well described. Our aim was to analyse spontaneous reports of hypoglycaemia registered in the French Pharmacovigilance database and to compare these data with two other step-2 analgesic drugs. METHODS: Cases of hypoglycaemia associated with TRM, dextropropoxyphene (DXP) and codeine (COD) recorded between 1997 and November 2010 in the French Pharmacovigilance database were compared. RESULTS: 72 cases of hypoglycaemia associated with DXP and 43 with TRM were retained for evaluation (the single case reported with COD was not further considered). Most patients were elderly people with no significant difference between DXP- and TRM-treated patients (71.2 ± 21 vs. 69.4 ± 22.5 years). Hypoglycaemia occurred after a median of 4 and 5 days with DXP and TRM treatment, respectively. The mean lowest serum glucose level was 2.1 ± 0.9 mmol/l in the DXP group compared to 2.5 ± 1 mmol/l in the TRM group (p= 0.072). At least, one risk factor of hypoglycaemia was found in most patients, with no significant difference between groups (58.3% in the DXP group and 58.1% in the TRM group). In particular, 31.9% patients from the DXP group had diabetes compared to 41.8 % from the TRM group (p = 0.28) and 18% of DXP patients had renal insufficiency compared to 16.3% of TRM patients (p = 0.8). CONCLUSIONS: Our study confirms that TRM is associated with the occurrence of hypoglycaemia in elderly or predisposed patients, with characteristics similar to those previously reported with DXP. |
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Authors:
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Cindy Bourne; Aurore Gouraud; Amélie Daveluy; Aurélie Grandvuillemin; Pascal Auriche; Jacques Descotes; Thierry Vial; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-4 |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: - ISSN: 1365-2125 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society. |
Affiliation:
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Centre de Pharmacovigilance, 162 avenue Lacassagne, 69003, Lyon, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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