Document Detail

Tramadol and hypoglycaemia: comparison with other step 2 analgesic drugs.
MedLine Citation:
PMID:  22943675     Owner:  NLM     Status:  MEDLINE    
AIMS: The risk of hypoglycaemia with tramadol (TRM) is not well described. Our aim was to analyze spontaneous reports of hypoglycaemia registered in the French Pharmacovigilance database and to compare these data with two other step-2 analgesic drugs.
METHODS: Cases of hypoglycaemia associated with TRM, dextropropoxyphene (DXP) and codeine (COD) recorded between 1997 and November 2010 in the French pharmacovigilance database were compared.
RESULTS: Seventy-two cases of hypoglycaemia associated with DXP and 43 with TRM were retained for evaluation (the single case reported with COD was not further considered). Most patients were elderly people with no significant difference in age between DXP- and TRM-treated patients (71.2 ± 21 vs. 69.4 ± 22.5 years). Hypoglycaemia occurred after a median of 4 and 5 days with DXP and TRM treatment, respectively. The mean lowest serum glucose concentration was 2.1 ± 0.9 mmol l(-1) in the DXP group compared with 2.5 ± 1 mmol l(-1) in the TRM group (P = 0.072). At least, one risk factor of hypoglycaemia was found in most patients, with no significant difference between groups (58.3% in the DXP group and 58.1% in the TRM group). In particular, 31.9% patients from the DXP group had diabetes compared with 41.8 % from the TRM group (P = 0.28) and 18% of DXP patients had renal insufficiency compared with 16.3% of TRM patients (P = 0.8).
CONCLUSIONS: Our study confirms that TRM is associated with the occurrence of hypoglycaemia in elderly or predisposed patients, with characteristics similar to those previously reported with DXP.
Cindy Bourne; Aurore Gouraud; Amélie Daveluy; Aurélie Grandvuillemin; Pascal Auriche; Jacques Descotes; Thierry Vial;
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  75     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-20     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1063-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. British Journal of Clinical Pharmacology © 2012 The British Pharmacological Society.
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MeSH Terms
Analgesics / adverse effects*
Blood Glucose / drug effects
Codeine / adverse effects*
Databases, Factual
Dextropropoxyphene / adverse effects*
France / epidemiology
Hypoglycemia / chemically induced,  epidemiology*
Risk Factors
Tramadol / adverse effects*
Reg. No./Substance:
0/Analgesics; 0/Blood Glucose; 39J1LGJ30J/Tramadol; Q830PW7520/Codeine; S2F83W92TK/Dextropropoxyphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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