Document Detail

Tramadol and 0.5% levobupivacaine for single-shot interscalene block: effects on postoperative analgesia in patients undergoing shoulder arthroplasty.
MedLine Citation:
PMID:  21971437     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the efficacy of tramadol as an adjuvant to the local anaesthetic solution in patients undergoing shoulder arthroscopy for rotator cuff tear after middle interscalene block (MIB).
METHODS: We enrolled 120 patients (ASA I-II), scheduled for arthroscopic surgery for rotator cuff tear. The patients were sedated with midazolam 0.02 mg/kg and haloperidol 2 mg i.v. before performing MIB. All subjects underwent a MIB with 0.4 mL/kg of 0.5% levobupivacaine. After computerized randomization, all patients were allocated in 1 of 3 groups, each including 40 subjects. Group Placebo (Group P) received 0.4 mL/kg of 0.5% levobupivacaine plus isotonic sodium chloride for MIB and isotonic sodium chloride i.m. Group "Perineural Tramadol" (Group TPN) received 0.4 ml/Kg of 0.5% levobupivacaine plus 1.5 mg/kg of tramadol perineurally and isotonic sodium chloride i.m. Group "Intramuscular Tramadol" (Group TIM) received 0.4 ml/Kg of 0.5% levobupivacaine plus isotonic sodium chloride perineurally and 1.5 mg/kg of tramadol i.m.
RESULTS: The MIB onset times were not statistically different in the three groups. The duration of analgesia was significantly longer in Groups TPN and TIM, where tramadol was administered, either i.m. or perineurally, compared with the placebo group. A significant statistical difference was found in the duration of analgesia between the group TPN and TIM.
CONCLUSION: The addition of tramadol to the local anaesthetic solution administered for MIB provided a longer duration of analgesia compared with placebo and i.m tramadol administration in patients undergoing arthroscopic surgery for rotator cuff tear.
F Alemanno; D Ghisi; A Fanelli; A Faliva; B Pergolotti; F Bizzarri; G Fanelli
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Minerva anestesiologica     Volume:  78     ISSN:  1827-1596     ISO Abbreviation:  Minerva Anestesiol     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-23     Completed Date:  2012-07-16     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  0375272     Medline TA:  Minerva Anestesiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  291-6     Citation Subset:  IM    
Department of Anesthesia and Pain Therapy, Ospedale San Camillo, Brescia, Italy.
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MeSH Terms
Adjuvants, Anesthesia / administration & dosage*
Analgesics, Opioid / administration & dosage*
Anesthetics, Local / administration & dosage*
Bupivacaine / administration & dosage,  analogs & derivatives
Double-Blind Method
Hypnotics and Sedatives / administration & dosage
Injections, Intramuscular
Isotonic Solutions / administration & dosage
Middle Aged
Nerve Block*
Pain Measurement
Pain, Postoperative / prevention & control*
Prospective Studies
Rotator Cuff / injuries,  surgery*
Sodium Chloride / administration & dosage
Time Factors
Tramadol / administration & dosage*
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Analgesics, Opioid; 0/Anesthetics, Local; 0/Hypnotics and Sedatives; 0/Isotonic Solutions; 2180-92-9/Bupivacaine; 27203-92-5/Tramadol; 7647-14-5/Sodium Chloride; A5H73K9U3W/levobupivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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