Document Detail

Training to criterion in eyeblink classical conditioning in Alzheimer's disease, Down's syndrome with Alzheimer's disease, and healthy elderly.
MedLine Citation:
PMID:  8652068     Owner:  NLM     Status:  MEDLINE    
The cholinergic antagonist scopolamine delays acquisition of eyeblink classical conditioning (EBCC) in rabbits and humans, but scopolamine-treated organisms eventually acquire conditioned responses (CRs). Patients with probable Alzheimer's disease (AD) and older adults with Down's syndrome (DS/AD) have disrupted cholinergic systems and perform EBCC very poorly. It was hypothesized that patients with probable AD and DS/AD, like scopolamine-injected organisms, would acquire CRs if given sufficient training. Twelve probable AD patients, 12 DS/AD patients, and 6 healthy elderly control individuals participated in 5 daily 90-trial sessions of EBCC. Fifty-eight percent of the probable AD, 92% of the DS/AD, and 100% of the control participants achieved learning criterion. Probable AD, DS/AD, and control participants had statistically significant increases in the percentage of CRs produced over 5 EBCC sessions. The neural substrate for EBCC was not eliminated in probable AD or DS/AD patients, although the learning mechanism was disrupted.
D S Woodruff-Pak; S Romano; M Papka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  110     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-08-01     Completed Date:  1996-08-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  22-9     Citation Subset:  IM    
Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / diagnosis,  physiopathology,  psychology*
Blinking* / physiology
Cholinergic Fibers / physiology
Conditioning, Classical* / physiology
Conditioning, Eyelid* / physiology
Down Syndrome / diagnosis,  physiopathology,  psychology*
Middle Aged
Reference Values
Retention (Psychology) / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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