Document Detail


Training-induced alterations of carbohydrate metabolism in women: women respond differently from men.
MedLine Citation:
PMID:  9729597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the hypothesis that glucose flux was directly related to relative exercise intensity both before and after a 12-wk cycle ergometer training program [5 days/wk, 1-h duration, 75% peak O2 consumption (VO2 peak)] in healthy female subjects (n = 17; age 23.8 +/- 2.0 yr). Two pretraining trials (45 and 65% of VO2 peak) and two posttraining trials [same absolute workload (65% of old VO2 peak) and same relative workload (65% of new VO2 peak)] were performed on nine subjects by using a primed-continuous infusion of [1-13C]- and [6,6-2H]glucose. Eight additional subjects were studied by using [6, 6-2H]glucose. Subjects were studied postabsorption for 90 min of rest and 1 h of cycling exercise. After training, subjects increased VO2 peak by 25.2 +/- 2.4%. Pretraining, the intensity effect on glucose kinetics was evident between 45 and 65% of VO2 peak with rates of appearance (Ra: 4.52 +/- 0.25 vs. 5.53 +/- 0.33 mg . kg-1 . min-1), disappearance (Rd: 4.46 +/- 0.25 vs. 5.54 +/- 0.33 mg . kg-1 . min-1), and oxidation (Rox: 2.45 +/- 0.16 vs. 4.35 +/- 0.26 mg . kg-1 . min-1) of glucose being significantly greater (P </= 0.05) in the 65% than in the 45% trial. Training reduced Ra (4.7 +/- 0.30 mg . kg-1 . min-1), Rd (4.69 +/- 0.20 mg . kg-1 . min-1), and Rox (3.54 +/- 0.50 mg . kg-1 . min-1) at the same absolute workload (P </= 0. 05). When subjects were tested at the same relative workload, Ra, Rd, and Rox were not significantly different after training. However, at both workloads after training, there was a significant decrease in total carbohydrate oxidation as determined by the respiratory exchange ratio. These results show the following in young women: 1) glucose use is directly related to exercise intensity; 2) training decreases glucose flux for a given power output; 3) when expressed as relative exercise intensity, training does not affect the magnitude of blood glucose flux during exercise; but 4) training does reduce total carbohydrate oxidation.
Authors:
A L Friedlander; G A Casazza; M A Horning; M J Huie; M F Piacentini; J K Trimmer; G A Brooks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  85     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-05     Completed Date:  1998-11-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1175-86     Citation Subset:  IM    
Affiliation:
Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, California 94720-3140, USA. friedlan@leland.stanford.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Glucose / metabolism
Body Composition / physiology
Carbohydrate Metabolism*
Exercise / physiology
Female
Hormones / blood
Humans
Lactic Acid / blood
Male
Menstruation / physiology
Oxygen Consumption / physiology
Physical Fitness / physiology*
Sex Characteristics
Grant Support
ID/Acronym/Agency:
AR-42906/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Hormones; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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