Document Detail

Training-induced adaptation of oxidative phosphorylation in skeletal muscles.
MedLine Citation:
PMID:  12741955     Owner:  NLM     Status:  MEDLINE    
Muscle training/conditioning improves the adaptation of oxidative phosphorylation in skeletal muscles to physical exercise. However, the mechanisms underlying this adaptation are still not understood fully. By quantitative analysis of the existing experimental results, we show that training-induced acceleration of oxygen-uptake kinetics at the onset of exercise and improvement of ATP/ADP stability due to physical training are mainly caused by an increase in the amount of mitochondrial proteins and by an intensification of the parallel activation of ATP usage and ATP supply (increase in direct stimulation of oxidative phosphorylation complexes accompanying stimulation of ATP consumption) during exercise.
Bernard Korzeniewski; Jerzy A Zoladz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  374     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-07     Completed Date:  2003-09-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Institute of Molecular Biology and Biotechnology, Jagiellonian University, ul. Gronostajowa 7, 30-387 Kraków, Poland.
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MeSH Terms
Adaptation, Physiological / physiology*
Adenosine Diphosphate / metabolism
Adenosine Triphosphate / metabolism
Computer Simulation
Models, Biological
Muscle, Skeletal / physiology*
Oxidative Phosphorylation*
Physical Endurance*
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 58-64-0/Adenosine Diphosphate

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