| Training increases peroxiredoxin 2 contents in the erythrocytes of overweight/obese men suffering from type 2 diabetes. | |
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MedLine Citation:
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PMID: 22160369 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Type 2 diabetes mellitus (T2DM) is associated with an increased release of free radicals which play an important role in the manifestation of diabetes and in the progression of diabetic complications. Peroxiredoxins are thought to be essential components of the erythrocyte antioxidative defense. Therefore, we compared peroxiredoxin isoform contents (PRDX1-6 immunohistochemial stainings) in the erythrocytes of overweight/obese T2DM men (n = 6) and of BMI-matched non-diabetic male control subjects (n = 6). Only erythrocyte PRDX1 and PRDX2 proteins were detectable using immunohistochemical methods. PRDX1 was significantly increased in T2DM men relative to control subjects (+95.9%, P ≤ 0.05). Furthermore, we studied the influence of a 3-month endurance training program (3 times a week, cycling at 75% maximal heart rate) on erythrocyte PRDX1 and PRDX2 contents in overweight/obese T2DM men (n = 11). Training significantly increased PRDX2 at rest (+96%, P ≤ 0.05). The up-regulation of the peroxiredoxin system may help counteract free radicals in the erythrocytes of T2DM patients. |
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Authors:
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David Assadi Moghaddam; Anke Heber; Dario Capin; Thorsten Kreutz; David Opitz; Edward Lenzen; Wilhelm Bloch; Klara Brixius; Christian Brinkmann |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Wiener medizinische Wochenschrift (1946) Volume: 161 ISSN: 1563-258X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708475 Medline TA: Wien Med Wochenschr Country: - |
Other Details:
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Languages: ENG Pagination: 511-518 Citation Subset: - |
Affiliation:
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Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany. |
Vernacular Title:
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Training erhöht die Peroxiredoxin-2-Gehalte in den Erythrozyten übergewichtiger/adipöser Typ-2-Diabetiker. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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